Projects

  • PainPlus

    PAIN+ CPN

    Project Title

    PainPLUS CPN

    Principal Investigator

    Alfonso Iorio

    Aim

    The aim of this IPRC supported project is to develop and maintain an evidence-based information service for health care practitioners engaged in the management of acute and chronic pain, in collaboration with the PainHQ website. In addition to including original and systematic review articles of relevance to all aspects of clinical pain care, the service provides dedicated streaming of neuropathic and post-stroke central neuropathic pain data. This service will provide a continuously updated, quality assessed, clinician rated on-line service, based on the McMaster PLUS Health Knowledge Refinery. Over 120 top clinical journals including leading pain journals are included in the assessment process (http://hiru.mcmaster.ca/hiru/journalslist.asp). This service is customized for pain specialists through recruiting clinical raters for articles, including pain specialist physicians, nurses, occupational therapists, physiotherapists, and clinical psychologists.

  • PainHQ

    PainHQ

    Project Title  

    DeGroote PainHQ

    Aim

    To serve as an online resource for individuals living with neuropathic pain. PainHQ provides access to a range of evidence-based resources, curated by the experts, rated by the public and supporting over two million Canadians living with neuropathy. The range of resources provided is, in part, what makes PainHQ unique. Personal stories, e-learning videos, webinars and expert blogs make up part of the site’s diverse offerings. The goal is to educate on neuropathic pain and to help make the condition more accessible to the general public. Building on McMaster's strengths in evidence-based medicine, health education and e-learning, PainHQ is an innovative and sustainable resource for patient-centred care.

  • Pain-STOP_web

    PAIN STOP

    Project Title

    PAIN STOP:  Preventing pAin with Nmda antagonists-Steroids in Thoracoscopic LObectomy Procedures

    Principal Investigator

    Harsha Shanthanna and PJ Devereaux

    Study Updates
    • Our target recruitment of 24 patients at St Joseph’s Hospital, Hamilton was achieved in February 2018.
    • As there was a significant procedural delay involving the ethics board at the Cleveland Clinic site, USA, the recruitment was initiated in April 2018.
    • The study drug “memantine/placebo” which was procured and packaged for use in February 2017, had an expiry month of April 2018. Further, the only company (pharmascience) that manufactured both 5 mg and 10 mg tablets and had a license for use in both Canada and the US, did not have any supply/stock of 5mg tables in April 2018.
    • In view of all these logistical challenges, the trial recruitment was stopped at the end of April-2018.
    • In total there have been 28 patients (target was 48) recruited for the trial. We have completed all the patient follow ups, data cleaning and data verification for the statistical analysis.
    • Presently, the study analysis plan has been approved by the primary investigators and is being reviewed by a statistician for final analysis.

  • Patient with cableless monitoring system

    SMArtVIEW

    Project Title

    TecHnology-Enabled remote monitoring and Self-MAnagemenT —VIsion for patient EmpoWerment following Cardiac and VasculaR surgery. (THE SMArTVIEW, CoVeRed)

    Principal Investigator

    Dr. Michael McGillion

    Partnerships  

    Philips Healthcare (Canada and UK); QoC Health Inc; XAHIVE; ThoughtWire; Coventry University; Cloud DX; Argyle Public Relationships; Hamilton Health Sciences; Ontario Telemedicine Network; Liverpool Heart and Chest Hospital

    Aim

    To determine the effect of the SMArTVIEW intervention compared to standard care on the 45-day risk of a composite of hospital readmission, urgent care center and emergency department visits (not requiring hospital admission), in patients, aged 65 years or older, who undergo cardiac or major vascular surgery.

  • Hip-Attack_Sized

    HIP ATTACK Trial

    Project Title

    Chronic Pain Sub-Study in HIP ATTACK (HIP fracture Accelerated surgical TreaTment and Care) Trial

    Principal Investigator

    Harsha Shanthanna and PJ Devereaux

    Aim

    The HIP ATTACK study is a multicentre, international, parallel group randomized controlled trial of patients looking at the effects of accelerated surgical repair (within 6 hours of diagnosis) versus standard care (i.e. surgery usually >24 hours after diagnosis). The original trial included 1200 patients. However, the sample size was revised in 2017 for 3000 patients with all-cause mortality being the primary outcome at 90 days after surgery.

  • cardiacpain

    FORESITE-VISION

    Project Title

    FORESITE-VISION: ‘Further Observation for chronic pain and poor functional recovery Risk Factor Examination at selected SITEs (FORESITE), a study in partnership with The Vascular events In Surgery patients cOhort evaluatioN – cardiac Surgery (VISION Cardiac Surgery)

    Principal Investigator

    McGillion, M., Busse, JW.

    Aim

    Funded by the CIHR and HAHSO, the specific objectives of FORESITE VISION are to examine the influence of cognitive factors, namely, pain-related beliefs and gender- based pain expectations, on the following outcomes up to 1 year following cardiac surgery: the development of CPSP, functional status, and patient- level cost of illness. With a view to comprehensive examination of the impact of CPSP on patients, an additional aim is to determine the impact of CPSP on quality adjusted life years (QALY) borne by cardiac surgery (a measure of disease burden, including the quality and quantity of life lived), as well as the incremental cost for one additional QALY gained for patients, by virtue of cardiac surgery, among those who develop CPSP compared to those who do not.

  • opioids

    Prevalence and risk factors associated with persistent use of opioids after surgery: A meta-analysis

    Project Title

    Prevalence and Risk Factors associated with persistent use of opioids after Surgery - A Meta-Analysis.

    Principal Investigator

    Jason Busse/Yasir Rehman

    Aim

    To conduct and meta-analysis and systematic review to explore the prevalence and risk factors associated with the prolonged opioid use after surgery.

  • cannabis

    Effect of Cannabinoid on PPSP after TKA

    Project Title

    The effect of cannabinoids vs. placebo on persistent post-surgical pain following total knee arthroplasty: A multicenter, randomized pilot trial

    Principal Investigator

    Jason Busse

    Aim

    The goal of the proposed pilot trial is to establish the feasibility of a larger trial by successfully recruiting 40 patients at 2 centres over a 6-month period and demonstrating adherence to our study protocol. Specific feasibility objectives include determining: 1. Ability to recruit 40 patients over six months 2. Ability to follow 85% of patients for 6 months 3. At least 75% of patients comply with at least 75% of study treatments doses

OTHER INITIATIVES


  • CPN_Logo_Final_EN_Resized

    Chronic Pain Network

    Principal Investigator

    Norm Buckley

    Aim

    The Chronic Pain Network (CPN), funded through the Strategy for Patient Oriented Research (SPOR) and matching funds from Network partners, is one of five addressing chronic disease. Reporting for the award began January 2016 and was originally set to conclude March 2021. Due to COVID-19, the Network was extended to 2022, with a call for an opportunity for renewal presented in the fall of 2021. 

    The Network seeks to change the way pain is managed in Canada through improved assessment, prevention and provision of timely and optimal pain management, and to reduce pain and improve function, participation and quality of life for those affected, while alleviating the economic burden of pain over one's lifespan.



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