Cancer poses a huge burden to society, with 1 in 2 Canadians expected to develop cancer in their lifetime. Exciting new treatments designed to cure cancer or extend survival, strategies to help people with cancer live well with their disease, cancer system design that optimizes the patient experience and puts resources where they are most needed, all provide rich and important opportunities for research. These represent important priorities for the Department of Oncology and research done in our Department has changed clinical practice, health systems and health policy locally, nationally and internationally. We remain committed to continuing this legacy by supporting our trainees in developing research skills, mentoring young investigators, collaborating with our colleagues in other disciplines and, most of all, pursuing research that makes a difference to people with cancer.