Current Projects

updated family stress logo

Project: Family Stress Study

Funding Agency: Canadian Institutes of Health Research (CIHR) & the McMaster COVID-19 Research Fund

Principal Investigators: Dr. Katherine Morrison & Dr. Jess Haines (University of Guelph) 

About the Family Stress Study: The daily lives of Canadian families have been impacted by the physical distancing requirements due to the COVID-19 pandemic. We worry about our family's well being, financial stability and overall stress levels. Our way of life has fundamentally shifted, and it is unknown how these changes and the added stress will affect our children’s health. While some stress can be good to motivate us to get things done, too much long term stress can have negative effects, especially on our youngest family members. Researchers at the University of Guelph and McMaster University are looking at how chronic or long-term stress affects children. We will follow caregivers and their oldest eligible child between 2-5 years old over 3 years to examine how stress in their family and home impacts their eating, activity and growth over time.

 

MIREC-ENDO-LOGO

Project: MIREC-ENDO

Funding Agency: Health Canada 

Local Principal Investigator: Dr. Katherine Morrison

About MIREC-ENDO: MIREC-ENDO (MIREC - Maternal-Infant Research on Environmental Chemicals, ENDO - short for endocrine) focuses on the onset and progression of puberty, metabolic function and growth.  Many people believe that puberty is beginning earlier and earlier, especially in girls. Unfortunately, the reason for this trend remains unclear. Some suspect that diet and body weight are factors, while others believe environmental chemicals may play a role. We also want to learn about the factors that may affect body weight and metabolism for both mothers and their children. Some studies suggest a possible link between environmental chemicals and the likelihood of being overweight. We hope to shed some light on this question as well. Because of the vast amount of data collected in the critical periods of infant and child development, MIREC is uniquely suited to be able to study factors affecting early or delayed puberty, growth and metabolic health. Metabolic health has been defined as ideal levels of blood sugar, triglycerides, high-density lipoprotein (HDL) cholesterol, blood pressure, and waist circumference, without using medication.

Project: The CHAMPION Study: Cardiovascular Health in children with a chronic inflAMmatory condition: role of Physical activity, fItness, and inflammatiON

Funding Agency: Heart & Stroke Foundation 

Principal Investigator: Dr. Brian Timmons

About the Study: Children growing up with a medical condition might be at a greater risk for heart disease than healthy children. We don’t know if this is because of their medical condition, or because of lifestyle factors, such as not getting enough exercise, or a combination of both. The goal of The CHAMPION Study is to study heart health, as well as the factors that might affect heart health, in the most common chronic diseases of childhood.

GETBAT team at annual retreat 2017

Project: Gene Environment Team on Brown/Beige Adipose Tissue (GET_BAT)

Funding Agency: Canadian Institutes of Health Research (CIHR)

Principal Investigators: Dr. Gregory Steinberg & Dr. Katherine Morrison

About GET_BAT: More than 5 million Canadians have obesity, non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) and their prevalence in the population is rapidly increasing. Centre Co-Directors, Greg Steinberg and Katherine Morrison, and their team, which includes André Carpentier (Sherbrooke), Alison Holloway, Waliul Khan, Andrew McArthur, Kei Sakamoto (Nestle), Jonathan Schertzer, Deborah Sloboda, and Michael Surette, are working to understand the underlying causes of these chronic, interrelated diseases. Brown adipose tissue (BAT), frequently characterized as the body’s furnace, has the unique capability to burn large amounts of sugar and fat, and effectively dissipates this energy as heat. In individuals with obesity or T2D the ability to switch on BAT is compromised, but the reasons for this are not well understood. The GET_BAT team is examining how agricultural and food processing practices may regulate BAT metabolic activity, directly, or indirectly by altering the gut microbiome. These studies will help us develop new strategies to enhance BAT activity that may be effective for treating and preventing obesity, NAFLD and T2D.

Project: Energy Sensing and Metabolism: From Mechanisms to New Therapies

Funding Agency: Canadian Institutes of Health Research (CIHR)

Principal Investigator: Dr. Gregory Steinberg

About the Project: The explosive increase in type 2 diabetes across Canada and around the world in all demographics and ethnicities poses a substantial risk not only to the individuals affected but to society at large given the huge economic burden of managing the serious events of the disease. It has been recognized for decades that there is a strong connection between type 2 diabetes and heart disease but despite substantial research there are very few treatments which effectively reduce the effects of type 2 diabetes on promoting heart disease. Dr. Steinberg studies key molecules/proteins which control how the body uses energy and is developing and testing new medicines that specifically impact these proteins in liver and adipose tissue in order to treat people with type 2 diabetes.

baby and mi and baby and pre-mi study logos

Projects: Baby & Mi and Baby & Pre-Mi Studies

Funding Agencies: Canadian Institutes of Health Research (CIHR) & Joint Programming Initiative "A Healthy Diet for a Healthy Life"

Principal Investigators: Dr. Eileen Hutton & Dr. Katherine Morrison

About Baby & Mi: The “ecosystem” of bacteria in our gut, also known as the gut flora or intestinal microbiota, is important to our health throughout our lives. Researchers think that the types of organisms that we pick up within the first weeks of life may determine the makeup of our gut bacteria for the long term. This study is among the first in North America to investigate factors that may alter the gut bacteria that we pick up in the first 3 years of life.

About Baby & Pre-Mi: The Baby & Pre-Mi Study is examining the microorganisms normally found in the gut that help us digest food and fight infections. We are interested in studying how premature babies pick up these microorganisms during birth and early life, and how they are connected to health. Participants will be followed with their single baby or twins until they are three years old.

canadian pediatric weight management registry

Project: Canadian Pediatric Weight Management Registry (CANPWR)

Funding Agency: Canadian Institutes of Health Research (CIHR)

Principal Investigator: Dr. Katherine Morrison

About CANPWR: The CANPWR Study is a national study that is measuring different health outcomes of children and youth registered in 10 different weight management programs across Canada. We aim to track the progress of our study participants over a 3-year period and identify what factors help individuals reach their goals in the weight management programs. 

Why is CANPWR Important: CANPWR will help us understand how the health of children changes when they are part of a program to help with their eating habits and physical activity. No one has collected this data before!

Recent Publications 

Peripheral and central regulation of insulin by the intestine and microbiome


AMERICAN JOURNAL OF PHYSIOLOGY : ENDOCRINOLOGY AND METABOLISM - January 2021

Postbiotics for NOD2 require nonhematopoietic RIPK2 to improve blood glucose and metabolic inflammation in mice


AMERICAN JOURNAL OF PHYSIOLOGY: ENDOCRINOLOGY AND METABOLISM - March 2020

Glucose alters the symbiotic relationships between gut microbiota and host physiology


AMERICAN JOURNAL OF PHYSIOLOGY: ENDOCRINOLOGY AND METABOLISM - February 2020

Participate

Participate in Research!

Researchers from the Centre for Metabolism, Obesity and Diabetes Research may need volunteers to participate in ongoing research studies. If you or your child are interested in participating in research, check out the studies that are currently accepting participants.

updated family stress logo

The FAMILY STRESS STUDY

Join the Family Stress Study to help researchers at McMaster University & the University of Guelph look at how stress affects young children. 

Working together, safely! We would love to meet your family, but to be safe, all data collection will be no contact at this time. All questionnaires are completed on-line. Everything you need to complete study measurements at home will be delivered to your doorstep by mail or no contact drop-off. Our team will be available through phone, email and video chat to answer any question you have! 

If you are interested in learning more about what is involved in participating in the study, please contact our research team! 

Website: Family Stress Study

Email: stress@mcmaster.ca

The CHAMPION Study

Cardiovascular Health in children with a chronic inflAMmatory condition: role of Physical activity, fItness and inflammatiON

Children growing up with a medical condition might be at a greater risk for heart disease than healthy children. We don’t know if this is because of their medical condition, or because of lifestyle factors, such as not getting enough exercise, or a combination of both. The goal of The CHAMPION Study is to study heart health, as well as the factors that might affect heart health, in the most common chronic diseases of childhood. This study is funded by the Heart & Stroke Foundation of Canada.

Click here to learn more about this study:

https://fhs.mcmaster.ca/chemp/champion.html

If you are interested in learning more about what is involved in participating in the study, please contact us:

Phone: 905-521-2100 ext. 73571

Email: obeidj@mcmaster.ca

Older Adults with Type 1 Diabetes

We are looking for men and women with and without type 1 diabetes (30 to 80 years-old) to participate in a research study regarding the health of their muscles. The information from this study will help us to better understand adult muscle health and will be extremely valuable when designing ways to prevent, slow, or even reverse muscle problems that are associated with aging and type 1 diabetes. If you are interested in participating, or want to know more about the study, please contact our research team!

Phone: 905-525-9140 ext. 21834

Email: type1musclehealthstudy@gmail.com

Collaborate

We are always looking for new Centre members and collaboration opportunities. It is our goal to not only work together as Centre members but to educate and train the next generation of clinicians and research scientists to significantly impact the health and well-being of Canadians across the lifecourse. 

Katherine Morrison (left) and Emily Day (right)

Centre Documents

Annual Report - Long Web Version April 1, 2020_Page_01

McMaster Centre for Metabolism, Obesity & Diabetes Research (MODR) Inaugural Annual Report

The McMaster Centre for Metabolism, Obesity and Diabetes Research (MODR) was founded in July 2018 with the mandate to develop new strategies for the prevention and treatment of chronic metabolic diseases. In this inaugural annual report, it is our pleasure to highlight some of the team’s key accomplishments to date.  

This report outlines the extensive research contributions made by members of the MODR team. We are delighted with the engagement and enthusiasm of the MODR members to collaborate to generate new knowledge, to translate knowledge across traditional silos and to develop scientists comfortable in the translational environment through experiential education.

To read the 2019 Annual Report, click the link below. 



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