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Dr. Austin and his research group have published over 160 peer-reviewed papers, book chapters and review articles. His research program is focused on understanding the underlying cellular stress pathways involved in the development and progression of cardiorenal and cardiometabolic diseases. Some of the major discoveries in Dr. Austin’s laboratory include (i) defining the role of endoplasmic reticulum (ER) stress in atherosclerotic lesion development and vascular calcification, (ii) demonstrating
a causal role of TDAG51 in atherosclerosis and obesity, and (iii) identifying the cellular factors that contribute to blood flow and fibrosis in the kidney. Inhibiting the pathological effects of ER stress can suppress many of the downstream pathways that contribute to atherosclerosis, obesity and renal disease. Currently his group is investigating the therapeutic potential of ER stress response pathways inhibition for the prevention or delayed onset of these diseases.
- To understand the biology and function of PCSK9 in cardiovascular disease
- To understand how gain- and loss-of-function variations in PCSK9 impact the risk of cardiovascular disease
- To provide evidence for the unique role of the loss-of-function PCSK9-Q152H variant in protection against liver injury/dysfunction4) To highlight future approaches aimed at targeting PCSK9 as a means of enhancing good health and longevity