Research
The Division of Neurology is committed to providing the best neurology by supporting and advancing research. The division is very research-intensive, particularly in stroke and cognition. Research is incorporated and an important activity in our postgraduate and fellowship programs.
NAVIGATE ESUS was a global trial lead by our stroke group at PHRI that tested a factor Xa inhibitor in patients with embolic stroke of undetermined source.
COMPASS-MIND was an MRI imaging sub-study of the COMPASS trial that evaluated the incidence of clinically silent brain ischemia. AXIOMATIC-SSP is a global phase 2 randomized trial of a novel factor XIa inhibitor for the prevention of recurrent stroke in patients after stroke or TIA.
ENRICH-AF is evaluating the use of a DOAC in high-risk atrial fibrillation patients with previous intracranial hemorrhage.
McMaster initiated hemorrhagic stroke studies include NASPAF-ICH, CoHESIVE, and SATURN, among others. The stroke group collaborates on many national and international stroke studies.
The MS program contributes to the Canadian Multiple Sclerosis Working Group recommendations. We contribute and work with the Ontario Neurodegenerative Disease Research Initiative (ONDRI) in ALS and Dementia. The ALS program is involved in a number of therapeutic drug trials and continues basic research in understanding the biology of ALS. European collaborations are investigating the development of automated methods for EEG seizure detection and the utility of slow-wave activity in EEG in patients with low-grade glioma.
Neurology residents have been very successful in research projects that include, identifying the utility of echocardiography in patients with stroke, investigating the cognitive function of patients with COPD, testing perineural hydrodissection for patients with carpal tunnel syndrome, and the development of an acute ischemic stroke and hemorrhagic stroke registries.
Further details on ongoing and completed research projects on Stroke & Cognition can be accessed in the Population Health Research Institute website.
Our Research in the News
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McMaster researchers developing homegrown vaccines to fight COVID-19 and prevent future outbreaks, using specialized campus lab and production facility
February 12, 2021 by Michelle Donovan
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World’s most cited researchers includes 16 from Faculty of Health Sciences
December 7, 2020
Sixteen Faculty of Health Sciences researchers are among 18 McMaster University affiliated scientists who have been recognized as among the top one per cent of scientists in the world according to their citations.
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McMaster ranked 11th internationally for medicine
December 2, 2020
McMaster University has been ranked 11th in the world for clinical, pre-clinical and health subjects by the Times Higher Education World University rankings for 2021.
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Department of Medicine Annual Awards Dinner 2020
November 30, 2020
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2020 Outstanding Researcher in Inflammatory Bowel Disease
November 9, 2020
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David Braley and Nancy Gordon Chair in Thromboembolic Disease
November 9, 2020
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Professors join Canadian Academy of Health Sciences
September 18, 2020
Five McMaster University professors, all members of the Faculty of Health Sciences, are joining the Canadian Academy of Health Sciences (CAHS) as fellows.
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McMaster Textbook of Internal Medicine widely accessed around the globe
September 15, 2020
It has been a year since the release of the McMaster Textbook of Internal Medicine, and already, it’s been accessed by tens of thousands of people around the world.
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Crohn’s and Colitis Canada 2019 Rising Star Award
September 10, 2020
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Researchers find clues to SARS-CoV-2 infection and explore why COVID-19 impacts patients differently
August 11, 2020
Working together, researchers at McMaster University and the University of Waterloo are searching for how the SARS-CoV-2 virus infects the lungs – and they’re challenging what has become an accepted truth about the virus.
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McMaster-led guidelines issued for new COVID-19 treatment
August 5, 2020
Much has been made recently about the new antiviral drug remdesivir for COVID-19 patients, but a McMaster University-led guideline for physicians warns that it would only be used in the most serious cases, and more research is needed.
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Malignant cancer diagnosed in a dinosaur for the first time
August 4, 2020
Researchers at McMaster University and the Royal Ontario Museum (ROM) have reported the discovery and diagnosis of an aggressive malignant bone cancer — an osteosarcoma — for the first time ever in a dinosaur.
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McMaster heads network to study deadly blood infections
July 23, 2020
A new McMaster University-based network will bring together researchers and patients to tackle sepsis — a leading cause of death in COVID-19.
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When race is a barrier to care in the Emergency Room
July 14, 2020
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Should masks be mandatory inside indoor public spaces?
July 13, 2020
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McMaster scoops up $20M more for COVID-19 research
June 25, 2020
McMaster University has garnered $20 million in new funding for 17 COVID-19 research projects from the Canadian Institutes of Health Research (CIHR) and their funding partners.
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Evidence shows cloth masks may help against COVID-19
May 25, 2020
The evidence shows that cloth masks, particularly those with several layers of cotton cloth, block droplet and aerosol contamination of the environment, may reduce transmission of COVID-19.
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