Research
Dr. Haider is the Lead and Developer for the CANMUS registry (Canadian Mucormycosis Registry) where the aim is to define the epidemiology, speciation of mucormycosis, treatment, and outcomes. He also participates in a study to define the burden of HCV in Haemophiliacs in Canada using the Canadian Blood Disorders Registry(CBDR) and applying the Cascade of Care to identify barriers to engagement in care. Dr. Woodward’s research focus is on HIV prevention (PrEP). He is a co-investigator in the Ontario PrEP Cohort and co-Investigator of Scaling Up PrEP Implementation, both of which are CHIR funded. Dr. Khan received funding from Hamilton Health Sciences to study antibiotic prophylaxis to prevent post-procedure urinary tract infection and voiding cystourethrogram.
Dr. Smaill is the Principal Investigator of a CIHR funded study on the safety and potency of a new tuberculosis vaccine delivered by inhaled aerosol to humans. CIHR and co-investigator on a study to improve vaginal health to decrease the biological risk of HIV-1 infection in Canadian Women. Dr. Mertz received a grant from HHS to prevent Clostridium difficile infections by identifying asymptomatic carriers. Dr. Loeb’s research team published the largest genetic study on dengue of > 9,000 participants showing that genetic variants across the genome can cause a large increase in risk of dengue hemorrhagic fever. This study was published in the Lancet journal EBioMedicine. His group completed a 3-year study comparing adjuvanted influenza vaccine to standard-dose vaccine in children. This is the first study to assess the effect of adjuvanted influenza vaccines to produce herd immunity. In the past year, Dr. Loeb exceeded his enrollment target of 5,000 participants in an MRC UK funded global MRC trial of influenza vaccine to prevent myocardial infarction, stroke, and other adverse vascular events. This study is being conducted in Asia, the Middle East, and Africa and is the largest study of its kind.
Dr. Mertz continues to conduct a multi-site cluster randomized trial of antibiotic prophylaxis for cardiac surgery. Drs. Mertz and Loeb published an important study assessing pregnancy as a risk factor for severe influenza using data from >180,000 patients from centres from all over the world. This study raises doubt about whether pregnancy is really a risk factor for severe outcomes of influenza infection. Over this past year, Dr. Mertz and Loeb led work that has contributed to the World Health Organization’s AWaRe program for the 2019 Essential Medicines List which has become a global antibiotic stewardship tool. Dr. Loeb has been leading a CIHR funded cohort study to better understand the natural history of people with Lyme disease in Canada. Dr. Loeb is funded by a CIHR Foundation Grant.
Our Research in the News
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Department of Medicine Annual Awards Dinner 2020
November 30, 2020
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2020 Outstanding Researcher in Inflammatory Bowel Disease
November 9, 2020
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David Braley and Nancy Gordon Chair in Thromboembolic Disease
November 9, 2020
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Professors join Canadian Academy of Health Sciences
September 18, 2020
Five McMaster University professors, all members of the Faculty of Health Sciences, are joining the Canadian Academy of Health Sciences (CAHS) as fellows.
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McMaster Textbook of Internal Medicine widely accessed around the globe
September 15, 2020
It has been a year since the release of the McMaster Textbook of Internal Medicine, and already, it’s been accessed by tens of thousands of people around the world.
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Crohn’s and Colitis Canada 2019 Rising Star Award
September 10, 2020
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Researchers find clues to SARS-CoV-2 infection and explore why COVID-19 impacts patients differently
August 11, 2020
Working together, researchers at McMaster University and the University of Waterloo are searching for how the SARS-CoV-2 virus infects the lungs – and they’re challenging what has become an accepted truth about the virus.
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McMaster-led guidelines issued for new COVID-19 treatment
August 5, 2020
Much has been made recently about the new antiviral drug remdesivir for COVID-19 patients, but a McMaster University-led guideline for physicians warns that it would only be used in the most serious cases, and more research is needed.
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Malignant cancer diagnosed in a dinosaur for the first time
August 4, 2020
Researchers at McMaster University and the Royal Ontario Museum (ROM) have reported the discovery and diagnosis of an aggressive malignant bone cancer — an osteosarcoma — for the first time ever in a dinosaur.
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McMaster heads network to study deadly blood infections
July 23, 2020
A new McMaster University-based network will bring together researchers and patients to tackle sepsis — a leading cause of death in COVID-19.
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When race is a barrier to care in the Emergency Room
July 14, 2020
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Should masks be mandatory inside indoor public spaces?
July 13, 2020
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McMaster scoops up $20M more for COVID-19 research
June 25, 2020
McMaster University has garnered $20 million in new funding for 17 COVID-19 research projects from the Canadian Institutes of Health Research (CIHR) and their funding partners.
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Evidence shows cloth masks may help against COVID-19
May 25, 2020
The evidence shows that cloth masks, particularly those with several layers of cotton cloth, block droplet and aerosol contamination of the environment, may reduce transmission of COVID-19.
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McMaster researchers rally to help Canadian company expedite new mask to meet urgent COVID-19 demand
April 14, 2020
Health sciences and engineering researchers at McMaster University have been racing to assist Woodbridge Foam Corporation in getting a new made-in-Canada mask designed, tested and certified, as supplies of existing medical masks become less certain.
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Project to answer last wishes spreads successfully
November 15, 2019
New McMaster research has found a program that honours dying patients by fulfilling end of life wishes can be powerful, affordable and sustainable in many settings.
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The essence of internal medicine is now in your hand
October 24, 2019 by Tina Depko, Health Sciences
The first edition of the McMaster Textbook of Internal Medicine is making its formal debut, fittingly, in time for the 50th anniversary celebrations of the Michael G. DeGroote School of Medicine this month.
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McMaster researchers reveal the ancient natural history of antibiotic production and resistance
August 14, 2019 by Christy Groves
A study from McMaster University has unearthed new details about the evolutionary history of both antibiotic production and resistance and dates their co-emergence as far back as 350 to 500 million years.
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Study offers insights into making surgery safer for patients taking direct oral anticoagulants
August 6, 2019
A Hamilton-led international study of more than 3,000 patients could set the stage globally for how patients can safely use blood-thinning medications before and after surgery to mitigate risk of bleeding and stroke. The Perioperative Anticoagulation Use for Surgery Evaluation (PAUSE) study was conducted across 23 clinical centres in Canada, United States and Europe.
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Most deaths related to non-cardiac surgery occur after surgery
July 29, 2019
It's the recovery period, not the operating room that is risky for patients undergoing non-cardiac surgery, according to a large international study led by McMaster University. Based on patients at 28 health centres in 13 countries, the results show less than one per cent of deaths of these patients occurred in the operating room, but 29 per cent of deaths occurred after discharge from hospital.
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McMaster clinical medicine ranked 29th in the world
July 11, 2019
The 2019 Global Ranking of Academic Subjects has ranked McMaster’s clinical medicine and civil engineering programs 29th in the world. The clinical medicine is ranked second in Canada, and the civil engineering program is third in the country.
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