A new study from the Jordana/Waserman lab, co-first authored by Kelly Bruton and Paul Spill and published in the Journal of Allergy and Clinical Immunology, investigates the critical interactions between T and B cells on IgE responses in peanut allergy. Peanut allergies are among the most prevalent food allergies to date and, with no transformative therapeutic interventions, pose a life-threatening risk to millions around the world. Understanding how these allergies persist is critical to developing effective therapies.
While it has been previously established that peanut allergies are the result of dominant Th2- and IgE-mediated immune responses, the cellular and molecular mechanisms of the recall response remained incompletely understood. In this study, the researchers integrated a novel in vitro human platform, targeted proteomics, and single cell transcriptomics to elucidate the interactions between T and B cells upon peanut exposure on the generation of IgE-secreting cells. They uncovered that in PBMCs from peanut allergic patients, the IL-4/IL-13 signaling axis was critical for IgE production and Th2 cytokine skewing. Strikingly, in allergic mice, they found that blockade of IL-4/IL-13 signalling through a monoclonal IL-4Rα antibody induced complete and sustained protection against IgE production and IgE-mediated anaphylaxis upon allergen challenge. Their findings provide critical insight into the potential of IL-4/IL-13 axis blockade to alter allergic disease and identify anti-IL-4Rα as a promising therapeutic for the treatment of food allergies.
Congratulations Kelly, Paul, Manel, and all co-authors on the publication of this impactful study!
Read the full study here