BBS Seminar Series - Jianhua Zhao - Molecular mechanism of TRPA1 activation by noxious chemicals

Schedule

Start 9 November, 2021, 11 30 AM

End 12 30 PM

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Location

Online

Via Zoom

No Province / Territory specified

Registration Required

Contact Info

Tracy Stojanovic

E-Mail: stojan@mcmaster.ca

No website provided


The 2021 Nobel Prize in Physiology was awarded to David Julius and Ardem Patapoutian for their pioneering work on the receptors of the somatosensory system, including transient receptor potential (TRP) ion channels. This talk will focus on my work with David Julius to understand the molecular mechanisms of how environmental and noxious stimuli activate the TRPA1 wasabi receptor. Using a combination of cryogenic electron microscopy and patch lamp electrophysiology, we deciphered a two-step mechanism of TRPA1 activation involving the modification of critical cysteines. This work helps to explain how TRPA1 is able to respond to a variety of chemical stimuli.

Registration is required. You can register here: https://us06web.zoom.us/webinar/register/WN_sjQpQRhkRXO5OuhN6RfrXA

TRAINEES: Join us! We will be hosting a virtual “Lunch and Learn” with the speaker from 12:30 – 1:00 pm.

If you are interested, please feel free to join the following link to participate: https://us06web.zoom.us/j/89474748961?pwd=NFQzTVRPZlpIMGxDOTdUTFlreWVZQT09


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