Registration for the 9th Annual MODR symposium is now open!
Dr. Michael Czech
Michael P. Czech is currently the Isadore and Fannie Foxman Professor at the University of Massachusetts Chan Medical School, where he was also Chairman of Biochemistry (1981-1989) and founding Chair of the Program in Molecular Medicine (1989-2018), which includes faculty research laboratories and Howard Hughes Medical Institute Investigators. Czech’s laboratory applies RNAi- and CRISPR-based technologies to address mechanisms of insulin signal transduction, metabolic regulation and insulin resistance in obesity and type 2 diabetes. His group’s work revealed insights into the structures and functions of receptors for insulin and the insulin-like growth factors, and identified several new regulators of adipose tissue and systemic metabolism. These include the lipid droplet proteins Cidec/Cidea, the co-repressor RIP140 and exchange factor GRP1. Czech is a member of the Scientific Review Board of the Howard Hughes Medical Institute. He has received the Elliot P. Joslin Medal (1998), the Banting Medal of the American Diabetes Association (2000), and the 2009 Jacobaeus Prize presented in Umea Sweden.
Dr. Christoph Thiele
Dr. Christoph Thiele obtained his PhD in chemistry and biochemistry at Freiburg and Frankfurt in 1994. He pursued a Post-Doc with Wieland Huttner in Heidelberg, where he researched protein sorting in regulated secretion and on protein-lipid interaction. In 2000, he was a Post-Doc with Gerrit van Meer in Amsterdam. From 2001-2009 Dr. Thiele was a group leader at MPI-CBG in Dresden, working on lipid droplets and various aspects of lipid related methodology. Since 2009, Dr. Thiele has been a full professor at Bonn University where his lab works on lipid tracing. His lab has recently developed a tracing technology that is based on alkyne fatty acids and a set of click reporter molecules optimized for MS detection (Thiele et al., Nature Methods 2019) and applied this to analysis of lipid metabolism in hepatocytes (Wunderling et al., Mol. Metab. 2021). Now, they add to the present multiplexing capabilities the possibility for multi-labeling with three different fatty acids in one sample. This allows the comprehensive tracing of fatty acid metabolism, following more than 400 lipid species labeled with three different fatty acids in 4x multiplexed samples. Dr. Thiele will present a time resolved analysis in 3T3-L1 adipocytes that opens a fresh view on the unexplored metabolic complexity of fatty acid storage.
Dr. Michael Noseworthy