Associate Professor

Biochemistry and Biomedical Sciences

RESEARCH INTERESTS: Use stem cell-based models to study neurological disorders and devise new therapies for these conditions.

Dr. Singh joined the SCC-RI for its unique commitment to working with human cells and its established proficiency in using stem cells to generate the tissue types needed to study human disease.

905-525-9140

singhk2@mcmaster.ca

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The overall goal of Dr. Karun Singh’s research program is to use stem cell-based models to study neurodevelopmental, neuropsychiatric and neurodegenerative disorders, and to devise new therapies for these conditions. His lab uses genetic mouse models and patient-derived induced pluripotent stem (iPS) cell technology to create 2D neural cells and 3D brain organoids. His lab is also interested in using emerging technologies to study abnormal signaling pathways in brain disorders, and to harness this information for drug screening and testing for future therapeutics. His lab has identified novel Autism risk genes and how they disrupt normal brain development using mouse and human cellular models. Future work in the Singh lab will use emerging genetic and proteomic technologies to study pathological signaling mechanisms in a wide-variety of neurological conditions.