NIH in Collaboration with Demystifying Medicine

  • NIH Demystifying Medicine: Neurofibromatosis Type 1 Tumors: Natural History To Precision Therapy

    April 26, 2022 by Brigitte Widemann, Jack Shern
    • Knowledge Translation
    Dr. Brigitte Widemann's pioneering research on NF1 resulted in 2020 in the first FDA-approved medical therapy, the MEK inhibitor selumetinib, for children with NF1 and inoperable, symptomatic plexiform neurofibromas. Dr. Jack Shern is attempting to detect and define the somatic lesions that drive tumorigenesis as well as trying to discover precision therapeutics designed to target a tumor's underlying genetic or epigenetic drivers.
  • NIH Demystifying Medicine: How Minds and Brains Create Language

    April 19, 2022 by Evelina Fedorenko, Nadia Biassou
    • Knowledge Translation
    Dr. Evelina Fedorenko uses behavioral and brain imaging methods in healthy adults, patients with acquired brain disorders, and "hyper-polyglots" with exceptional linguistic talent to investigate how we understand and produce language. Dr. Nadia Biassou is dedicated clinical educator, she has taught community physicians cutting-edge radiologic interpretation in various clinical settings throughout the Americas.
  • NIH Demystifying Medicine: Seeing Biology and Physics in Space

    April 12, 2022 by John Mather
    • Knowledge Translation
    JWST an infrared telescope 100 times more powerful than the famed Hubble Space Telescope. Among its goals is to observe the very first stars and galaxies to form in the universe, to map stellar and galactic evolution over a period of 13 billion years, and to search for biosignatures or signs of life on planets beyond our solar system. Dr. John Mather is a senior astrophysicist at the NASA Goddard Space Flight Center, the senior project scientist for the JWST, and is the co-recipient of the 2006 Nobel Prize in Physics for measuring key properties of the Big Bang.
  • NIH Demystifying Medicine: Endocrine Disrupters and Fertility

    April 5, 2022 by Lyuba Varticovski, Alan DeCherney
    • Knowledge Translation
    Despite being crucial to the survival of our species, fertility surprisingly eludes millions of couples worldwide. Lyuba Varticovski, a hematologist and oncologist, an important focus of her research has been detecting and quantifying endocrine disruptors such as contaminants in water that activate nuclear receptors affecting humans and other life in the broader ecosystem. Alan DeCherney, an obstetrician and gynecologist, studies the cellular and molecular elements of blastocyst development and implantation on the lining of the uterus and has made numerous important discoveries with implication for clinical fertility.
  • NIH Demystifying Medicine: Chronic COVID - Neurologic and Mental Effects

    March 29, 2022 by Walter Koroshetz, Joshua Gordon
    • Knowledge Translation
    Dr. Walter Koroshetz, NINDS Director since 2015 and member of the National Academy of Medicine, has conducted research on excitotoxicity, a cause of neuronal cell death. Dr. Joshua Gordon, NIMH Director since 2016, employs a range of systems neuroscience techniques, including in vivo imaging, anesthetized and awake behavioral recordings, and optogenetics to study schizophrenia, anxiety disorders, and depression.
  • NIH Demystifying Medicine: Tiny Technologies and Medicine From Hepatic Tissue Engineering to Cancer Nanotechnology

    March 22, 2022 by Sangeeta Bhatia
    • Knowledge Translation
    Sangeeta Bhatia, director of the Marble Center for Cancer Nanomedicine at the Koch Institute, studies how micro- and nanoscale systems can be deployed to understand, diagnose, and treat human disease. In the area of the liver, her lab is developing microtechnology tools to understand how ensembles of cells coordinate to produce tissues with emergent properties in the body. In the area of cancer, the lab is developing nanotechnology tools to meet the challenge of delivering cargo into the tumor microenvironment where transport is dominated by diffusion.
  • NIH Demystifying Medicine: Somatic Mutations in “Benign” Diseases - Somatic Mutations in Rheumatologic Diseases: VEXAS And Beyo

    March 15, 2022 by Neal Young, Peter Grayson
    • Knowledge Translation
    Neal Young, who leads the Cell Biology Section in the National Heart, Lung, and Blood Institute (NHLBI), has transformed the understanding and treatment of bone marrow failure. Peter Grayson, a tenure-track investigator who leads the Vasculitis Translational Research Program in the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). Seeks to identify factors that cause vasculitis, which is characterized by an inflammation of blood vessels. Grayson hopes to find biomarkers that can predict clinical outcomes and guide patient-specific therapeutic decisions.
  • NIH Demystifying Medicine: Brain Development in Adolescents and Addiction Risks - Digital Phenotyping

    March 8, 2022 by Nora Volkow, Brenda Curtis
    • Knowledge Translation
    Nora Volkow is director of the National Institute on Drug Abuse and a principal investigator in the NIH Intramural Research Program. Her body of research has been instrumental in demonstrating that drug addiction is a brain disorder. Brenda Curtis is a principal investigator in NIDA Translational Addiction Medicine Branch. Her research focus is translational, leveraging social media and big data methodology to form the development, evaluation, and implementation of technology-based tools that address substance use and related conditions such as HIV/AIDS.
  • NIH Demystifying Medicine: Origin of Life: Viewed by evolutionary biologist and cell biologist

    March 1, 2022 by Jennifer Lippincott-Schwartz,
    • Knowledge Translation
    Dr. Lippincott-Schwartz is a senior group leader at Howard Hughes Medical Institute's Janelia Research Campus and former chief of the NIH NICHD Section on Organelle Biology. Her research has revealed how the organelles of eukaryotic cells are dynamic, self-organized structures that constantly regenerate themselves through intracellular vesicle traffic, rather than static structures. Lippincott-Schwartz also is an innovator of live, subcellular microscopy. Her collaborative work at the NIH on photoactivatable GFP led to the development of super-resolved fluorescence microscopy, which was recognized in a 2014 Nobel Prize in Chemistry awarded to her colleague Eric Betzig.
  • NIH Demystifying Medicine: Reimagining the Taxonomy of Autoinflammatory Disease

    February 22, 2022 by Dan Kastner, Kalpana Manthiram, Daniella Schwartz
    • Knowledge Translation
    Dan Kastner is an NIH Distinguished Investigator and chief of the Inflammatory Disease Section in the NHGRI Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch. Kalpana Manthiram is a newly appointed Assistant Clinical Investigator in the NIAID Cell Signaling and Immunity Section, having completed a fellowship in Dr. Kastner's lab. Daniella Schwartz is an Assistant Clinical Investigator in the NIAID Laboratory of Allergic Diseases, where she sees patient volunteers, investigates relationships between allergic inflammation and autoimmune problems, and has worked with Drs. Kastner and Manthiram on the riddle of autoinflammatory disorders.
  • NIH Demystifying Medicine: The Mighty Mitochondrion and its Diseases

    February 15, 2022 by Richard Youle, Derek Narendra
    • Knowledge Translation
    Richard Youle, a senior investigator in the NINDS Biochemistry Section, has elucidated how the body clears damaged mitochondria and thereby protects against numerous diseases, including Parkinson's. Derek Narendra is a Lasker Clinical Research Scholar in the NINDS Inherited Movement Disorders Unit. With a focus on Early Onset Parkinson's Disease, his lab has discovered that two genes, Parkin and PINK1, function in a novel mitochondrial quality control pathway in which impaired mitochondria are targeted for lysosomal degradation by mitophagy.
  • NIH Demystifying Medicine: Epigenetic Contribution to Autoimmune Diseases and Anticytokine Autoantibodies

    February 8, 2022 by Lindsey Criswell, Steven Holland
    • Knowledge Translation
    Dr. Lindsey Criswell, director of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), has contributed to the identification of more than 30 genes linked to these disorders using genome-wide association and other genetic studies. Dr. Steven Holland, NIH Distinguished Investigator and director of the intramural program at the National Institute of Allergy and Infectious Diseases (NIAID), employs an integrated bench-to-bedside model in laboratory work and in the clinical appreciation of disease, which together add new insights into mechanisms of action and avenues of therapy.
  • NIH Demystifying Medicine: Defining Genes Underlying Mendelian Immunological Disorders Leads To Precision Medicine

    February 1, 2022 by Michael Lenardo, Helen Su
    • Knowledge Translation
    Michael Lenardo, co-director of the NIAID Clinical Genomics Program, has made great strides in using genomic approaches for treating autoimmune conditions such as multiple sclerosis and type 1 diabetes mellitus. Helen Su, chief of the Human Immunological Diseases Section in NIAID's Laboratory, patients with a spectrum of poorly characterized, inherited immunodeficiencies and autoimmune diseases who lack molecular diagnoses.
  • NIH Demystifying Medicine: Reflections on SARS-COV-2 Pandemic and Innate Immunity

    January 25, 2022 by Luba Vikhanski, Robert Gallo
    • Knowledge Translation
    Luba Vikhanski, a science writer at the Weizmann Institute of Science, is the author of "Immunity: How Elie Metchnikoff Changed the Course of Modern Medicine." Robert Gallo, co-founder and director of the Institute of Human Virology, is recognized internationally for his co-discovery of HIV as the cause of AIDS during his long tenure at the NIH.
  • NIH Demystifying Medicine: The Role of the Microbiome / How Gut Microbiome Controls Liver Tumors

    January 18, 2022 by Jeffrey Gordon, Tim Greten
    • Knowledge Translation
    Jeffrey Gordon, Program Director at Washington University, is known internationally for his lab's research on how gut microbial communities affect normal intestinal function. Tim Greten, senior investigator at the NIH, is an expert in gastrointestinal and tumor oncology whose lab hopes to better understand how liver tumors interact with the immune system.
  • NIH Demystifying Medicine: The Split Personality of Helicobacter Pylori

    January 11, 2022 by Barry Marshal, Martin Blaser
    • Knowledge Translation
    Barry Marshal is a 2005 Nobel prize winner for his demonstration of H. pylori as an agent of gastritis and peptic ulcer disease, while Martin Blaser is the director of the CABM at Rutgers who uses H. pylori as a model system for human health.
  • NIH Demystifying Medicine: COVID Then, Now, and the Future/The global challenge: COVID and Future Pandemics

    January 4, 2022 by Anthony Fauci, Roger Glass
    • Knowledge Translation
    Anthony Fauci, a stranger to no one at the NIH, has been a public face of the COVID pandemic response since January 2020, meanwhile, Roger Glass has helped to guide the U.S. international response to the COVID pandemic.

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