Demystifying Medicine Video



Many people are unaware that allocating donor organs remains to be a prominent limitation in performing transplant surgeries. The waiting list for recipients awaiting an organ has been increasing and often recipients are admitted into the hospital on life support while they wait. Ex-Vivo Lung Perfusion (EVLP) is a medical procedure that could potentially reduce wait times by modifying a donor’s lungs to improve the post-operation outcomes and overall survival rate. Dr. Steve Singh, a renowned cardiac surgeon joins the discussion to provide insight on EVLP.
 

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References
  • Fisher, A., Andreasson, A., Chrysos, A., Lally, J., Mamasoula, C., Exley, C., ... & Dark, J. (2016). An observational study of Donor Ex Vivo Lung Perfusion in UK lung transplantation: DEVELOP-UK. Health Technology Assessment, 20(85), 1-276.
  • Nelson, K., Bobba, C., Eren, E., Spata, T., Tadres, M., & Hayes, D. (2015). Method of isolated ex vivo lung perfusion in a rat model: lessons learned from developing a rat EVLP program. Journal of visualized experiments: JoVE, (96).
  • Organ donation Statistics. (2021, February 25). HRSA. Retrieved from https://www.organdonor.gov/statistics...
  • Tian, D., Wang, Y., Shiiya, H., Sun, C. B., Uemura, Y., Sato, M., & Nakajima, J. (2020). Outcomes of marginal donors for lung transplantation after ex vivo lung perfusion: A systematic review and meta-analysis. The Journal of thoracic and cardiovascular surgery, 159(2), 720-730.
  • International Thoracic organ Transplant (TTX) Registry. (2020). ISHLT. Retrieved from https://ishlt.org/research-data/regis...
  • Valenza, F., Rosso, L., Coppola, S., Froio, S., Palleschi, A., Tosi, D., ... & Gattinoni, L. (2014). Ex vivo lung perfusion to improve donor lung function and increase the number of organs available for transplantation. Transplant International, 27(6), 553-561.



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