Demystifying Medicine Video

Aortic valve stenosis is a severe valve disease that is characterized by a narrowing of the aortic valve. In this video, we define aortic valve stenosis, go over the signs and symptoms, and review the causes of this disease. We then compare and contrast various treatments for this disease, such as surgical aortic valve replacement, transcatheter aortic valve replacement, and balloon valvuloplasty. The purpose of this video is to inform those who are not familiar with aortic valve stenosis and to provide general information for those affected by the disease.

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  • Arora, S., Strassle, P. D., Kolte, D., Ramm, C. J., Falk, K., Jack, G., ... & Vavalle, J. P. (2018). Length of stay and discharge disposition after transcatheter versus surgical aortic valve replacement in the United States. Circ Cardiovasc Interv, 11(9).
  • Bergler-Klein, J., Klaar, U., Heger, M., Rosenhek, R., Mundigler, G., Gabriel, H., ... & Baumgartner, H. (2004). Natriuretic peptides predict symptom-free survival and postoperative outcome in severe aortic stenosis. Circulation, 109(19), 2302-2308.
  • Harky, A., Chaplin, G., Chan, J. S. K., Eriksen, P., MacCarthy-Ofosu, B., Theologou, T., & Muir, A. D. (2020). The future of open heart surgery in the era of robotic and minimal surgical interventions. Heart Lung Circ, 29(1), 49-61.
  • Malouf, J., Le Tourneau, T., Pellikka, P., Sundt, T. M., Scott, C., Schaff, H. V., & Enriquez-Sarano, M. (2012). Aortic valve stenosis in community medical practice: Determinants of outcome and implications for aortic valve replacement. J Thorac Cardiovasc Surg, 144(6), 1421-1427. doi:10.1016/j.jtcvs.2011.09.075
  • Nkomo V.T., Gardin J.M., Skelton T.N., Gottdiener J.S., Scott C.G., Enriquez-Sarano M. (2006). Burden of valvular heart diseases: a population-based study. Lancet, 368,1005–1011. doi: 10.1016/S0140-6736(06)69208-8
  • Osnabrugge R. L., Mylotte D., Head S. J., Van Mieghem N. M., Nkomo V. T., LeReun C. M., Bogers A. J., Piazza N., Kappetein A. P. (2013). Aortic stenosis in the elderly: disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modelling study. J Am Coll Cardiol, 62,1002–1012. doi: 10.1016/j.jacc.2013.05.015
  • Roberts, W. C., & Ko, J. M. (2005). Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation. Circulation, 111(7), 920-925.
  • Siontis, G. C., Overtchouk, P., Cahill, T. J., Modine, T., Prendergast, B., Praz, F., ... & Windecker, S. (2019). Transcatheter aortic valve implantation vs. surgical aortic valve replacement for treatment of symptomatic severe aortic stenosis: an updated meta-analysis. Eur Heart J, 40(38), 3143-3153.

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