Demystifying Medicine Video

How does COVID-19 infect and disrupt our brain? In this video, we continue our exploration of the neurological impacts of COVID-19 by delving into the cellular mechanisms of how the virus infects and causes damage in our brain. Included is a brief refresher on relevant scientific concepts such as basic brain anatomy and functions. We then move onto the first major hypothesis of infection; the pathway of the virus from inhalation into our nose to the region of our brain that senses smell. Next, the video discusses the specific protein on the surface of the virus that enables it to enter our cells, and how our body’s response actually results in weakening our blood-brain barrier, and the hormone system that COVID-19 interferes with. In the style of a webinar, this video’s purpose is to be informative and establish a foundation for individuals to seek out further knowledge.

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Author Details


  • Hayhurst, Chris. The Brain and the Spinal Cord: Learning How We Think, Feel, and Move. New York. The Rosen Publishing Group, Inc. 2002. p.33, 35, 37
  • Jäkel S, Dimou L. Glial cells and their function in the adult brain: a journey through the history of their ablation. Frontiers in cellular neuroscience. 2017 Feb 13;11:24.
  • Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ. Structure and function of the blood–brain barrier. Neurobiology of disease. 2010 Jan 1;37(1):13-25.
  • Action potentials and synapses [Internet]. Queensland Brain Institute. The University of Queensland; 2017 [cited 2020Nov16]. Available from:
  • Levi M, Keller TT, van Gorp E, ten Cate H. Infection and inflammation and the coagulation system. Cardiovascular research. 2003 Oct 15;60(1):26-39. Fotuhi M, Mian A, Meysami S, Raji CA. Neurobiology of COVID-19. J Alzheimers Dis. 2020 Jun 30;76(1):3–19.
  • Buzhdygan TP, DeOre BJ, Baldwin-Leclair A, Bullock TA, McGary HM, Khan JA, et al. The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier. Neurobiol Dis. 2020 Dec 1;146:105131
  • Alenina N, Bader M. ACE2 in Brain Physiology and Pathophysiology: Evidence from Transgenic Animal Models. Neurochem Res. 2018 Nov 15;44(6):1323–9.
  • Zubair AS, McAlpine LS, Gardin T, Farhadian S, Kuruvilla DE, Spudich S. Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019: A Review. JAMA Neurology. 2020 May 29.
  • Montalvan V, Lee J, Bueso T, De Toledo J, Rivas K. Neurological manifestations of COVID-19 and other coronavirus infections: A systematic review. Clinical Neurology and Neurosurgery. 2020 Jul 1;194:105921.
  • Nuzzo D, Picone P. Potential neurological effects of severe COVID-19 infection. Neuroscience Research. 2020 Jul 3.

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