Demystifying Medicine Video

Treatment-resistant depression (TRD) is a subtype of depression where individuals fail to achieve remission following multiple antidepressant therapies. Ketamine is a new and emerging treatment that shows promise in treating TRD. This video discusses how ketamine works and common side effects.

Disclaimer: Ketamine infusion therapy is an experimental treatment that, as of November 2020, is not approved by the FDA. If you are interested in ketamine infusion therapy for TRD, visit your family doctor or psychiatrist to learn more about your eligibility.

Helpful resources:

  • Find a healthcare provider at:

Find free, confidential online therapy at:


Canada Suicide Prevention Services (available 24/7/365):

  • Call 833-456-4566, or text 741741

Learn more about depression and other resources at:


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Author Details


  • Gill, H., Gill, B., Rodrigues, N.B., Lipsitz, O., Rosenblat, J.D., El-Halabi, S., Nasri, F., Mansur, R.B., Lee, Y., McIntyre, R.S. (2020). The Effects of Ketamine on Cognition in Treatment-Resistant Depression: A Systematic Review and Priority Avenues for Future Research, Neuroscience & Biobehavioral Reviews. DOI: 10.1016/j.neubiorev.2020.11.020
  • GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. (2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 392(10159), 1789–1858.
  • Rosenblat, J. D., McIntyre, R. S., Alves, G. S., Fountoulakis, K. N., & Carvalho, A. F. (2015). Beyond Monoamines-Novel Targets for Treatment-Resistant Depression: A Comprehensive Review. Current Neuropharmacology, 13(5), 636–655.

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