Demystifying Medicine Video



As the most common liver disease in the world, Hepatitis B is a life-threatening liver infection caused by the hepatitis B virus, or HBV. It can cause chronic infection and put people at a high risk of death from cirrhosis (scarring of the liver) and liver cancer. In 2015, 257 million people were living with a chronic form of hepatitis B, and almost 900,000 people died from it. In this video, you’ll learn a bit about the background of hepatitis B, its symptoms, transmission, molecular mechanism, prevention, and treatment!

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References
  • Boni, C., Fisicaro, P., Valdatta, C., Amadei, B., Vincenzo, P. D., Giuberti, T., . . . Ferrari, C. (2007). Characterization of Hepatitis B Virus (HBV)-Specific T-Cell Dysfunction in Chronic HBV Infection. Journal of Virology, 81(8), 4215-4225. doi:10.1128/jvi.02844-06
  • Hepatitis B Foundation. (2020). What is Hepatitis B. https://www.hepb.org/what-is-hepatiti...
  • Janeway C. et al. Immunobiology: The Immune System in Health and Disease. 5th edition. New York: Garland Science; 2001. T cell-mediated cytotoxicity. Available from: https://www.ncbi.nlm.nih.gov/books/NB...
  • Lumley SF, McNaughton AL, Klenerman P, Lythgoe KA and Matthews PC (2018) Hepatitis B Virus Adaptation to the CD8+ T Cell Response: Consequences for Host and Pathogen. Front. Immunol. 9:1561. doi: 10.3389/fimmu.2018.01561
  • Oh, I., & Park, S. (2015). Immune-mediated Liver Injury in Hepatitis B Virus Infection. Immune Network, 15(4), 191. doi: 10.4110/in.2015.15.4.191
  • Schuch, A., Hoh, A., & Thimme, R. (2014). The role of natural killer cells and CD8+ T cells in hepatitis B virus infection. Frontiers in immunology, 5, 258. doi: 10.3389/fimmu.2014.00258
  • Seeger, C., & Mason, W. S. (2015). Molecular Biology of Hepatitis B Virus Infection. Virology, 0, 672–686. https://doi.org/10.1016/j.virol.2015....
  • WHO. (2020). Hepatitis B. https://www.who.int/news-room/fact-sh...
  • Ye, B. et al. (2015). T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance. Cell Death & Disease, 6(3), e1694-e1694. doi: 10.1038/cddis.2015.42



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