Demystifying Medicine Video

Xeroderma Pigmentosum (XP) is a rare hereditary skin condition. It is the body’s extreme sensitivity to ultraviolet (UV) light due to the damage in the DNA repair mechanism. In this video, we will discuss what XP is, the DNA mechanism that causes XP, ongoing research to find a cure, as well as diagnosis, symptoms and disease management.
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Author Details


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  • Cleaver J. E. (2008). Diagnosis of Xeroderma Pigmentosum and Related DNA Repair-Deficient Cutaneous Diseases. Current medical literature. Dermatology, 13(2), 41–48.
  • DiGiovanna, J. J., & Kraemer, K. H. (2012). Shining a light on xeroderma pigmentosum. Journal of investigative dermatology, 132(3), 785-796
  • Kemp, M. G., & Sancar, A. (2012). DNA excision repair: where do all the dimers go?. Cell Cycle, 11(16), 2997-3002.
  • Lin, P., & English, J. C. (2004). Topical Treatment of Xeroderma Pigmentosum. P AND T, 29, 512-514. Mareddy, S., Reddy, J., Babu, S., & Balan, P. (2013). Xeroderma pigmentosum: man deprived of his right to light. TheScientificWorldJournal, 2013, 534752.
  • Mullenders, L. H., Stary, A., & Sarasin, A. (2001). Atlas of Genetics and Cytogenetics in Oncology and Haematology. Retrieved from
  • National Organization for Rare Disorders (NORD). (2017, August 04). Xeroderma Pigmentosum. Retrieved from

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