Demystifying Medicine Video



The complement system is part of the immune system. Its main function is to guide phagocytic cells and clear microbes and damaged cells from an organism. In this video, we introduce the role of C3 protein and how the protein can kill bacteria with/without the help from the other parts of the immune system. The video ends with an illustration of how those powerful tiny bombs (proteins) contribute to the progression of Alzheimer’s disease.
 
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References
  • Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Analyzing Protein Structure and Function. In: Molecular Biology of the Cell. 4th edition. New York, US: Garland Science, 2002.
  • Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Protein Function. In: Molecular Biology of the Cell. 4th edition. New York, US: Garland Science, 2002.
  • Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. The Shape and Structure of Proteins. In: Molecular Biology of the Cell. 4th edition. New York, US: Garland Science, 2002.
  • Bayly-Jones C, Bubeck D, Dunstone MA. The mystery behind membrane insertion: a review of the complement membrane attack complex. Philos Trans R Soc Lond B Biol Sci 2017; 372. DOI:10.1098/rstb.2016.0221.
  • Bohlson SS, O’Conner SD, Hulsebus HJ, Ho M-M, Fraser DA. Complement, c1q, and c1q-related molecules regulate macrophage polarization. Front Immunol 2014; 5: 402.
  • Carson MJ, Doose JM, Melchior B, Schmid CD, Ploix CC. CNS immune privilege: hiding in plain sight. Immunol Rev 2006; 213: 48–65. Daneman R, Prat A. The blood-brain barrier. Cold Spring Harb Perspect Biol 2015; 7: a020412.
  • Hartz AMS, Bauer B, Soldner ELB, et al. Amyloid-β contributes to blood-brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy. Stroke 2012; 43: 514–23.
  • Lodish H, Berk A, Zipursky SL, Matsudaira P, Baltimore D, Darnell J. Section 15.2: Overview of Membrane Transport Proteins. In: Molecular Cell Biology. 4th edition. New York, US: W. H. Freeman, 2000.
  • Merle NS, Noe R, Halbwachs-Mecarelli L, Fremeaux-Bacchi V, Roumenina LT. Complement System Part II: Role in Immunity. Front Immunol 2015; 6: 257. Morgan BP. Complement in the pathogenesis of Alzheimer’s disease. Semin Immunopathol 2018; 40: 113–24.
  • Noris M, Remuzzi G. Overview of complement activation and regulation. Semin Nephrol 2013; 33: 479–92. Ow S-Y, Dunstan DE. A brief overview of amyloids and Alzheimer’s disease. Protein Sci 2014; 23: 1315–31.
  • Parra-Medina R, Quintero-Ronderos P, Rodríguez ÉG. Chapter 4: The complement system. In: Anaya JM, Shoenfeld Y, Rojas-Villarraga A, Levy RA, Cervera R, eds. Autoimmunity: From Bench to Bedside. Bogota, Colombia: El Rosario University Press, 2013.
  • Priego N, Valiente M. The Potential of Astrocytes as Immune Modulators in Brain Tumors. Front Immunol 2019; 10: 1314.
  • Sarma JV, Ward PA. The complement system. Cell Tissue Res 2011; 343: 227–35.
  • Singhrao SK, Neal JW, Rushmere NK, Morgan BP, Gasque P. Spontaneous classical pathway activation and deficiency of membrane regulators render human neurons susceptible to complement lysis. Am J Pathol 2000; 157: 905–18.
  • Yang I, Han SJ, Kaur G, Crane C, Parsa AT. The role of microglia in central nervous system immunity and glioma immunology. J Clin Neurosci 2010; 17: 6–10.