Demystifying Medicine Video



Thalassemia is a blood disorder caused by the malformation of red blood cells in the body which results from the abnormal formation of hemoglobin. This video will take you through an overview of the condition, including a discussion of the molecular mechanisms of its pathology, symptoms, diagnosis, current and novel treatments that aim to cure the condition.

As thalassemia is a rare disorder, the video will elucidate the difficulties associated with being diagnosed from the perspective of the patient or a loved one and the importance of maintaining hope throughout the process.

[Please complete our feedback form]





References
  • Achwal, A. (2018). Extreme Fatigue/Tiredness in Kids—Causes, Symptoms & Treatment. https://parenting.firstcry.com/articl...
  • Bolaños-Meade, J., Cooke, K. R., Gamper, C. J., Ali, S. A., Ambinder, R. F., Borrello, I. M., Fuchs, E. J., Gladstone, D. E., Gocke, C. B., Huff, C. A., Luznik, L., Swinnen, L. J., Symons, H. J., Terezakis, S. A., Wagner-Johnston, N., Jones, R. J., & Brodsky, R. A. (2019). Effect of increased dose of total body irradiation on graft failure associated with HLA-haploidentical transplantation in patients with severe haemoglobinopathies: a prospective clinical trial. The Lancet Haematology. https://doi.org/10.1016/S2352-3026(19...
  • CDC. (2016). Thalassemia: Complications and Treatment | CDC. Centers for Disease Control and Prevention. https://www.cdc.gov/ncbddd/thalassemi...
  • Cunningham, M. J., Macklin, E. A., Neufeld, E. J., Cohen, A. R., & Network, the T. C. R. (2004). Complications of β-thalassemia major in North America. Blood, 104(1), 34–39. https://doi.org/10.1182/blood-2003-09...
  • Fibach, E., & Rachmilewitz, E. A. (2017). Pathophysiology and treatment of patients with beta-thalassemia - an update. In F1000Research. https://doi.org/10.12688/f1000researc...
  • Howland, G. (2018). Natural Ways to Treat Jaundice in Newborn Babies. Mama Natural. https://www.mamanatural.com/jaundice-...
  • Jaundice—Pre, Intra, Post-hepatic—Management. (n.d.). TeachMeSurgery. Retrieved November 13, 2020, from https://teachmesurgery.com/hpb/presen...
  • Karakas, S., Tellioglu, A. M., Bilgin, M., Omurlu, I. K., Caliskan, S., & Coskun, S. (2016). Craniofacial Characteristics of Thalassemia Major Patients. The Eurasian Journal of Medicine, 48(3), 204–208. https://10.5152/eurasianjmed.2016.150013
  • Lee, Y. K., Kim, H. J., Lee, K., Park, S. H., Song, S. H., Seong, M. W., Kim, M., & Han, J. Y. (2019). Recent progress in laboratory diagnosis of thalassemia and hemoglobinopathy: A study by the Korean Red Blood Cell Disorder Working Party of the Korean Society of Hematology. Blood Research. https://doi.org/10.5045/br.2019.54.1.17
  • Olivieri, N. F., & Brittenham, G. M. (2013). Management of the thalassemias. Cold Spring Harbor Perspectives in Medicine. https://doi.org/10.1101/cshperspect.a...
  • Thalassemias. (n.d.). Retrieved October 26, 2020, from https://www.nhlbi.nih.gov/health-topi...
  • WHO | Global epidemiology of haemoglobin disorders and derived service indicators. (n.d.). WHO; World Health Organization. Retrieved November 5, 2020, from https://www.who.int/bulletin/volumes/...