Demystifying Medicine Video



In recent months, the relationship between the medication Hydroxychloroquine and the treatment or prevention of Covid-19 has generated a lot of buzz. This video highlights recent research evidence regarding the use of Hydroxychloroquine for Covid-19. We also discuss the traditional uses of Hydroxychloroquine, and the potential side-effects that have been associated with this medication.
This video was created for educational and entertainment purposes only, and is not a substitute for professional medical advice. If you have questions about any medical condition or treatment, always seek the advice of your physician or other qualified healthcare provider.

[Please complete our feedback form]





References
  • Angelakis, E., et. al. (2014). Abnormal weight gain and gut microbiota modifications are side effects of long-term doxycycline and hydroxychloroquine treatment. Antimicrobial agents and chemotherapy, 58(6), 3342-3347
  • Boulware, D. R., et. al. (2020). A randomized trial of hydroxychloroquine as postexposure prophylaxis for Covid-19. New England Journal of Medicine. 
  • Celı̇k, I., Onay-Besı̇kcı̇, A., & Ayhan-Kilcigı̇l, G. (2020). Approach to the mechanism of action of hydroxychloroquine on SARS-CoV-2: a molecular docking study. Journal of Biomolecular Structure and Dynamics, 1-7.  
  • Chatre, C., Roubille, F., Vernhet, H., Jorgensen, C., & Pers, Y. M. (2018). Cardiac complications attributed to chloroquine and hydroxychloroquine: a systematic review of the literature. Drug safety, 41(10), 919-931.
  • ClinicalTrials.gov. Bethesda (MD): National Library of Medicine (US). Search of: Hydroxychloroquine: Covid19 - List Results. (2020 October 24). Retrieved
  • Cohen, M. S. (2020). Hydroxychloroquine for the Prevention of Covid-19—Searching for Evidence.  
  • Coronavirus (COVID-19) Update: FDA Revokes Emergency Use Authorization for Chloroquine and Hydroxychloroquine.
  • Fantini, J., Di Scala, C., Chahinian, H., & Yahi, N. (2020). Structural and molecular modeling studies  reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection. International journal of antimicrobial agents, 105960.  
  • Gao, J., Tian, Z., & Yang, X. (2020). Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Bioscience Trends, 14(1), 72–73. https:// doi.org/10.5582/bst.2020.01047 
  • Gevers, S., Kwa, M. S. G., Wijnans, E., & van Nieuwkoop, C. (2020). Safety considerations for chloroquine and hydroxychloroquine in the treatment of COVID-19. Clinical Microbiology and Infection, 26(9), 1276-1277.
  • Hernandez, A. V., Roman, Y. M., Pasupuleti, V., Barboza, J. J., & White, C. M. (2020). Hydroxychloroquine or chloroquine for treatment or prophylaxis of COVID-19: a living systematic review. Annals of Internal Medicine. 
  • Liu, J., Cao, R., Xu, M., Wang, X., Zhang, H., Hu, H., Li, Y., Hu, Z., Zhong, W., Wang, M. (2020). Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 Infection in vitro. Cell Discovery, 6(1), 1–4. 
  • Martins, A. C., Cayotopa, A. D. E., Klein, W. W., Schlosser, A. R., Silva, A. F. D., Souza, M. N. D., ... & da Silva-Nunes, M. (2015). Side effects of chloroquine and primaquine and symptom reduction in malaria endemic area (Mâncio Lima, Acre, Brazil). Interdisciplinary perspectives on infectious diseases, 2015.
  • Naghipour, S., Ghodousi, M., Rahsepar, S., & Elyasi, S. (2020). Repurposing of well- known   medications as antivirals: hydroxychloroquine and chloroquine–from HIV-1 infection to COVID-19. Expert Review of Anti-infective Therapy, 1-15.  
  • Ochsendorf, F. R., & Runne, U. (1991). Chloroquine and hydroxychloroquine: side effect profile of important therapeutic drugs. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 42(3), 140-146.
  • Sharma, A. N., Mesinkovska, N. A., & Paravar, T. (2020). Characterizing the adverse dermatologic effects of hydroxychloroquine: a systematic review. Journal of the American Academy of Dermatology.
  • Srinivasa, A., tosounidou, S., & gordon, C. (2017). Increased incidence of gastrointestinal side effects in patients taking hydroxychloroquine: a brand-related issue?. The Journal of rheumatology, 44(3), 398-398.
  • Wallace, D. (1996). The history of antimalarials. Lupus, 5, 2-3. doi:10.1177/0961203396005001021
  • Yusuf, I. H., Sharma, S., Luqmani, R., & Downes, S. M. (2017). Hydroxychloroquine retinopathy. Eye, 31(6), 828-845.
  • Zhou, D., Dai, S.-M., & Tong, Q. (2020). COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression. Journal of Antimicrobial Chemotherapy, 75(7), 1667–1670



Accessibility for Ontarians With Disabilities Act (AODA)

 

The Faculty of Health Sciences is committed to providing a website that is accessible to the widest possible audience. If there is an accessibility issue with this website, please contact us at fhsweb@mcmaster.ca.