Demystifying Medicine Video



The creation of CRISPR has propelled science in the 21st century. However, there are still some concerns regarding its "off switch." Anti-CRISPR allows this mechanism to be halted, provided novel mechanisms and therapeutic opportunities.

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References
  • Nakamura, M., Srinivasan, P., Chavez, M., Carter, M. A., Dominguez, A. A., La Russa, M., ... & Gao, Y. (2019). Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells. Nature communications, 10(1), 1-11.
  • National Academies of Sciences, E., Medicine,. (2017). Human Genome Editing: Science, Ethics, and Governance. Washington, DC: The National Academies Press.
  • Pawluk, A., Amrani, N., Zhang, Y., Garcia, B., Hidalgo-Reyes, Y., Lee, J., ... & Davidson, A. R. (2016). Naturally occurring off-switches for CRISPR-Cas9. Cell, 167(7), 1829-1838
  • Zhu, Y., Gao, A., Zhan, Q., Wang, Y., Feng, H., Liu, S., ... & Gao, P. (2019). Diverse mechanisms of CRISPR-Cas9 inhibition by type IIC anti-CRISPR proteins. Molecular cell, 74(2), 296-309.