Demystifying Medicine Video



This video investigates West Nile virus with an in-depth overview of the underlying mechanisms of viral infection and transmission. This topic has continued to be of high interest in the medical world as researchers and physicians strive to eliminate the threat of West Nile virus infection. The video first details what the virus is, how prevalent it is across different regions and how the symptoms of infection by this virus can be identified. It will then explain the mechanisms of viral infection and transmission. West Nile virus is a vector-borne virus that is transmitted to humans by mosquitoes. Once bitten by an infected mosquito, the viral particles transport throughout the body via the blood, stimulating infection through various means. These include, but are not limited to, passive transport through the endothelium or spread to the olfactory bulb. From here, endocytosed viral particles release their genomic content into the host cell where new viral particles are then formed and released, causing lysis of the host cell. Next, the video looks at current cures and preventative measures. Lastly, the video explores the methods in which scientists and physicians should approach West Nile Virus prevention in the future.

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References
  • Brinton, M.A. (2013). Replication cycle and molecular biology of the West Nile virus. Viruses, 6(1):13-53. doi: 10.3390/v6010013.
  • Colpitts, T. M., Conway, M. J., Montgomery, R. R., & Fikrig, E. (2012). West Nile Virus: biology, transmission, and human infection. Clin Microbiol Rev, 25(4): 635–648. doi: 10.1128/CMR.00045-12
  • Samuel, M.A., Diamond, M.S. (2006). Pathogenesis of West Nile Virus Infection: a Balance between Virulence, Innate and Adaptive Immunity, and Viral Evasion. J Virol, 80(19): 9349–9360. doi: 10.1128/JVI.01122-06
  • West Nile virus. (2017). World Health Organization.