Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that has no cure. Recently scientists have successfully used the CRISPR-Cas9 gene editing tool to remove the mutated SOD1 gene in a mouse model that mimics ALS. This video uses a combination of interviews and drawings to educate the general public about ALS and CRISPR. Dr. John Turnbull is a professor of Neurology at McMaster University and a neurologist and director of the ALS Clinic at Hamilton Health Sciences. Dr. John Turnbull conducts ALS research and speaks about ALS in this video. Vladimir Ljubicic is an assistant professor of kinesiology and Canada Research Chair (Tier 2) in Neuromuscular Plasticity in Health and Disease. Ljubicic's laboratory studies the mechanisms that regulate the maintenance and remodelling of the neuromuscular system in health and disease.