Demystifying Medicine Video



This video looks at several different outcome measures that are used to measure the effectiveness of treatments in ALS clinical trials. The video also covers some basic information surrounding ALS, symptoms of the disease, pathophysiology, clinical trials and current drugs under investigation. Dr. John Turnbull also speaks about several of the outcome measures that are currently used. Dr. Turnbull, a neurologist and researcher at McMaster University, has made significant contributions in the area of ALS research.

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References
  • Andrews, J. A., Miller, T. M., Vijayakumar, V., Stoltz, R., James, J. K., Meng, L., ... & Malik, F.I. (2018). CK‐2127107 amplifies skeletal muscle response to nerve activation in humans. Muscle & Nerve, 57(5), 729-734.
  • Cedarbaum, J. M., Stambler, N., Malta, E., Fuller, C., Hilt, D., Thurmond, B., ... & 1A complete listing of the BDNF Study Group. (1999). The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. Journal of the Neurological Sciences, 169(1-2), 13-21.
  • ALS Association Golden West Chapter. Disease mechanisms. (n.d.).
  • Gothelf, Y., Kaspi, H., Abramov, N., & Aricha, R. (2017). miRNA profiling of NurOwn®: mesenchymal stem cells secreting neurotrophic factors. Stem Cell Research & Therapy, 8(1), 249.
  • Kaji, R., Kodama, M., Imamura, A., Hashida, T., Kohara, N., Ishizu, M., ... & Kimura, J. (1998). Effect of ultrahigh‐dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: A double‐blind controlled study. Muscle & Nerve, 21(12), 1775-1778.
  • Paganoni, S., Cudkowicz, M., & Berry, J. D. (2014). Outcome measures in amyotrophic lateral sclerosis clinical trials. Clinical Investigation, 4(7), 605.
  • Shefner, J. M., & Gooch, C. L. (2003). Motor unit number estimation. Physical Medicine and Rehabilitation Clinics of North America, 14(2), 243-260.
  • Shiffman, C. A., Aaron, R., & Rutkove, S. B. (2015). U.S. Patent No. 9,014,797. Washington, DC: U.S. Patent and Trademark Office.
  • ALS Canada. Symptoms. (n.d.).
  • Van der Ploeg, R. J. O., Oosterhuis, H. J. G. H., & Reuvekamp, J. (1984). Measuring muscle strength. Journal of Neurology, 231(4), 200-203.
  • ALS Canada. What is ALS? (n.d.).