Demystifying Medicine Video



A study called Aspirin in Reducing Events in the Elderly (ASPREE) has been getting a lot of coverage lately, we will explore this topic through a CNN article titled "With daily low-dose aspirin use, risks may outweigh benefits for older adults." This video provides background information on aging and aspirin. It also discusses the impacts and reliability of the ASPREE study.

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References
  • McNeil, J., Woods, R., Nelson, M., Reid, C., Kirpach, B., Wolfe, R., Storey, E., Shah, R., Lockery, J., Tonkin, A., Newman, A., Williamson, J., Margolis, K., Ernst, M., Abhayaratna, W., Stocks, N., Fitzgerald, S., Orchard, S., Trevaks, R., Beilin, L., Donnan, G., Gibbs, P., Johnston, C., Ryan, J., Radziszewska, B., Grimm, R. and Murray, A. (2018). Effect of Aspirin on Disability-free Survival in the Healthy Elderly. New England Journal of Medicine, 379(16), pp.1499-1508.
  • Cuzick, J., Thorat, M. A., Bosetti, C., Brown, P. H., Burn, J., Cook, N. R., Ford, L.G., Jacobs, E.J., Jankowski, J.A., La Vecchia, C., Law, M., Meyskens, F., Rothwell, P.M., Senn, H.J., Umar, A. (2014). Estimates of benefits and harms of prophylactic use of aspirin in the general population. Annals of Oncology, 26(1), 47-57. doi:10.1093/annonc/mdu225
  • U.S. Department of Health and Human Services. (2017). Aspirin for Reducing Your Risk of Heart Attack and Stroke: Know the Facts. Retrieved 14 Oct 2018.
  • Hankey, G.J., and Eikelboom, J.W. (2003). Antiplatelet drugs. Med. J. Aust. 178, 568–574.
  • Harris, R., Beebe-Donk, J., Doss, H., & Doss, D. (2005). Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: A critical review of non-selective COX-2 blockade (Review). Oncology Reports, 13(4). doi:10.3892/or.13.4.559
  • Newton, J.L. (2006). Improving the gastrointestinal tolerability of aspirin in older people. Clin Interv Aging 1, 33–39.
  • Sneader, W. (2000). The discovery of aspirin: a reappraisal. BMJ 321, 1591–1594.
  • Tinker, B. (2018). With daily low-dose aspirin use, risks may outweigh benefits for older adultsRetrieved 14 Oct 2018.
  • Vane, J.R., and Botting, R.M. (2003). The mechanism of action of aspirin. Thromb. Res. 110, 255–258.