Demystifying Medicine Video



With the constantly evolving nature of cancer, various treatment modalities have come into focus. Cancer immunotherapy is an umbrella term for many new and promising treatments that work by modulating a patient's own immune system in order to combat their specific form of cancer. This video explores CAR T-cell therapy — a treatment that increases the specificity of a patient's T-Cells for tumour cells in their body. Although there are a number of drawbacks that are currently associated with this treatment, it has been shown to be very effective against certain blood cancers, such as acute lymphoblastic leukemia (ALL) and some B-cell malignancies.

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References
  • Park J, Rivière I, Gonen M et al. Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia. New England Journal of Medicine. 2018;378(5):449-459. doi:10.1056/nejmoa1709919.
  • Beatty G, Gladney W. Immune Escape Mechanisms as a Guide for Cancer Immunotherapy. Clinical Cancer Research. 2014;21(4):687-692. doi:10.1158/1078-0432.ccr-14-1860.
  • Zhang C, Liu J, Zhong J, Zhang X. Engineering CAR-T cells. Biomark Res. 2017;5(1). doi:10.1186/s40364-017-0102-y.
  • Fesnak A, June C, Levine B. Engineered T cells: the promise and challenges of cancer immunotherapy. Nature Reviews Cancer. 2016;16(9):566-581. doi:10.1038/nrc.2016.97.