Demystifying Medicine Video



What is PEP? PEP (Post-Exposure Prophylaxis) is antiretroviral therapy where individuals take medications orally in order to reduce the chances of acquiring HIV following possible exposure, which may occur from contact with bodily fluids either through sexual activity or injections. This video provides an overview of how PEP works to reduce the chances of acquiring HIV and discusses the effectiveness of the drug zidovudine as part of a case-control study. Zidovudine is a type of antiretroviral medication that is a controlled drug that must be proscribed by qualified medical professionals.


[Please complete our feedback form]



References
  • Cardo, D. M., Culver, D. H., Ciesielski, C. A., Srivastava, P. U., Marcus, R., Abiteboul, D., . . . Bell, D. M. (1997). A Case–Control Study of HIV Seroconversion in Health Care Workers after Percutaneous Exposure. New England Journal of Medicine,337(21), 1485-1490. doi:10.1056/nejm199711203372101
  • Hazuda, D. J., & Arts, E. J. (2012). HIV-1 Antiretroviral Drug Therapy. Cold Spring Harbour Perspectives in Medicine. doi:10.1101/cshperspect.a007161
  • HIV/AIDS. (2017, June 06). Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention. Retrieved October 01, 2017.
  • Merchant, R. C., & Keshavarz, R. (2001). Human Immunodeficiency Virus Postexposure Prophylaxis for Adolescents and Children. Pediatrics,108(2). doi:10.1542/peds.108.2.e38
  • The epidemiology of HIV in Canada. (n.d.). Community AIDS Treatment Information Exchange (CATIE). Retrieved October 01, 2017.
  • Wilen, C. B., Tilton, J. C., & Doms, R. W. (2011). Molecular Mechanisms of HIV Entry. Viral Molecular Machines Advances in Experimental Medicine and Biology,223-242. doi:10.1007/978-1-4614-0980-9_10
  • Young, T., Arens, F., Kennedy, G., Laurie, J., & Rutherford, G. (2005). Antiretroviral post-exposure prophylaxis (PEP) for occupational HIV exposure. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.cd002835.pub2