Dr. Morteza Ahmadi talks about the development of an implantable bioartificial kidney.
- Demand for kidney transplants significantly exceeds the supply
- Not much new development in technology since dialysis machine in 1943
- Challenges: technological, financial (high-risk investment), regulatory and reimbursement.
- What is the direction of innovation for renal replacement? miniaturization: wearable or implantable
- Implantable kidneys: cell-seeded decellularized rat kidney, 3D printing kidneys and UCSF implantable bioartificial kidney
- Use nanoporous silicon membranes to filter blood
- Solute filtration, hemolysis, hemocompatibility, code silicon with blood compatible material and cell adhesion
- Use combination of two nanofilters
- Nanofilter properties: hemo compatibility, durability and mimicking kidney filtration
- Animal testing for artificial kidney device