Professor

Coordinator, Regional Clinical Programs in Respirology; St. Joseph's Healthcare Hamilton

Medicine, Respirology

RESEARCH INTERESTS: Mechanisms of disease and development of novel strategies for diagnosis and therapy based on improved understanding of how respiratory diseases arise. Current projects examine the accumulation of cells during pulmonary inflammation and the structural consequences of chronic inflammation. Clinical research examines the potential for lung cancer to be detected using the examination of sputum. In collaboration with Dr. John Miller of the Division of Thoracic Surgery, Dr. Cox is examining the potential role of bronchial thermoplasty (a bronchoscopic procedure) as a treatment for asthma.

In addition to general respirology, Dr. Cox has a special interest in interstitial lung diseases such as sarcoidosis and pulmonary fibrosis.

905-525-9140 ext. 34929

coxp@mcmaster.ca

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Education and Professional Standing

Dr. Cox qualified in 1981 from UCD, Ireland. He trained in respiratory medicine at McMaster University and continued training in basic science at McMaster University and at the University of Iowa, Iowa City. He joined the faculty at McMaster University in 1992 where he continued his research into the basic mechanisms that control inflammation during respiratory diseases. Currently, he is Head of Acute Clinical Services at the Firestone Institute for Respiratory Health, at St. Joseph’s Healthcare Hamilton. In addition, he is President of the Canadian Thoracic Society.

Clinical Interests

In addition to general respirology, Dr. Cox has a special interest in interstitial lung diseases such as sarcoidosis and pulmonary fibrosis. In association with Dr. Martin Kolb, he runs a dedicated clinic at FIRH-SJHH, caring for patients with these uncommon disorders.

Selected Publications

• Induced sputum: Validity of fluid-phase IL-5 measurement. JACI 2000; 105:1162-8
• NO+ but not free radical relaxes airway smooth muscle via cGMP-independent release of internal Ca2+. Am J Physiol Lung Cell Mol Physiol 2000; 278
• Excitatory and inhibitory actions of isoprostanes in human and canine airway smooth muscle. J Pharmacol and Exper Therapeutics 2000; 295:506-511
• Eosinophil cationic protein relates to sputum neutrophil counts in health subjects. JACI 2000;106:593-4
• A randomized, controlled trial comparing thorascopy and limited thoracotomy for lung biopsy in interstitial lung disease. Ann Thorac Surg 2000; 70:1647-50
• Nicotine replacement combined with a novel compound (ProBAN ) for smoking cessation: a pilot study. Can Respir J 2001; 163:85-90
• Coronary and laryngeal spasm provoked by methacholine inhalation. JACI 2001; 107:392-3
• Increased detection of interluekin-5 in sputum by addition of protease inhibitors. Eur Respir J. 2001; 18:685-91
• The effect of air filtration systems on asthma: A systematic review of randomized trials. Chest. 2002 Nov;122 (5):1535-42
• Cysteinyl leukotrienes and human airway smooth muscle migration. Am J Respir Crit Care Med. 2002 Sep 1; 166 (5):738-42

Professor

Coordinator, Regional Clinical Programs in Respirology; St. Joseph's Healthcare Hamilton

Medicine, Respirology

RESEARCH INTERESTS: Mechanisms of disease and development of novel strategies for diagnosis and therapy based on improved understanding of how respiratory diseases arise. Current projects examine the accumulation of cells during pulmonary inflammation and the structural consequences of chronic inflammation. Clinical research examines the potential for lung cancer to be detected using the examination of sputum. In collaboration with Dr. John Miller of the Division of Thoracic Surgery, Dr. Cox is examining the potential role of bronchial thermoplasty (a bronchoscopic procedure) as a treatment for asthma.

In addition to general respirology, Dr. Cox has a special interest in interstitial lung diseases such as sarcoidosis and pulmonary fibrosis.

905-525-9140 ext. 34929

coxp@mcmaster.ca

---

Education and Professional Standing

Dr. Cox qualified in 1981 from UCD, Ireland. He trained in respiratory medicine at McMaster University and continued training in basic science at McMaster University and at the University of Iowa, Iowa City. He joined the faculty at McMaster University in 1992 where he continued his research into the basic mechanisms that control inflammation during respiratory diseases. Currently, he is Head of Acute Clinical Services at the Firestone Institute for Respiratory Health, at St. Joseph’s Healthcare Hamilton. In addition, he is President of the Canadian Thoracic Society.

Clinical Interests

In addition to general respirology, Dr. Cox has a special interest in interstitial lung diseases such as sarcoidosis and pulmonary fibrosis. In association with Dr. Martin Kolb, he runs a dedicated clinic at FIRH-SJHH, caring for patients with these uncommon disorders.

Selected Publications

• Induced sputum: Validity of fluid-phase IL-5 measurement. JACI 2000; 105:1162-8
• NO+ but not free radical relaxes airway smooth muscle via cGMP-independent release of internal Ca2+. Am J Physiol Lung Cell Mol Physiol 2000; 278
• Excitatory and inhibitory actions of isoprostanes in human and canine airway smooth muscle. J Pharmacol and Exper Therapeutics 2000; 295:506-511
• Eosinophil cationic protein relates to sputum neutrophil counts in health subjects. JACI 2000;106:593-4
• A randomized, controlled trial comparing thorascopy and limited thoracotomy for lung biopsy in interstitial lung disease. Ann Thorac Surg 2000; 70:1647-50
• Nicotine replacement combined with a novel compound (ProBAN ) for smoking cessation: a pilot study. Can Respir J 2001; 163:85-90
• Coronary and laryngeal spasm provoked by methacholine inhalation. JACI 2001; 107:392-3
• Increased detection of interluekin-5 in sputum by addition of protease inhibitors. Eur Respir J. 2001; 18:685-91
• The effect of air filtration systems on asthma: A systematic review of randomized trials. Chest. 2002 Nov;122 (5):1535-42
• Cysteinyl leukotrienes and human airway smooth muscle migration. Am J Respir Crit Care Med. 2002 Sep 1; 166 (5):738-42