Bernardo Trigatti, or Dino, has been working at the Hamilton General with TaARI, since January 2010. He says as a child, he was fascinated by nature and constantly asking questions. This led to an interest in research. “I’ve always been interested in discovery and asking questions and finding answers,” he says.
With TaARI, Trigatti’s research has been focused on causes and prevention of atherosclerosis. Atherosclerosis, also known as the hardening of the arteries, is caused by a build-up of cholesterol in the blood vessels and can reduce blood flow to key organs such as the heart and brain.
This is not to say all cholesterol is bad, Trigatti says. “All cells need cholesterol to grow . . . but too much cholesterol can build up and causes problems.” He is researching the interaction of cells in transferring cholesterol into and out of artery walls.
Cholesterol is made inside cells and then gets packaged into lipoproteins, which transport the cholesterol through the blood stream. If a person has high levels of a type of lipoprotein called LDL in their blood, cholesterol can build up in the artery walls.
Normally, cells in people’s immune system clear the arteries by taking in the cholesterol themselves. These inflammatory cells then release the cholesterol to an “acceptor”, which is usually another lipoprotein called HDL. The HDL then carries the cholesterol to the liver where it can be recycled or eliminated.
This process occurs in everyone, but many people suffering from atherosclerosis have trouble moving cholesterol to the liver so it builds up, hardening in their arteries.
No general related URL provided
No related news for this person
Department of Biochemistry and Biomedical Sciences
McMaster Children's Hospital 1280 Main St W HSC - 4N59 Hamilton, Ontario, Canada L8S 4K1
Monday to Friday 8:30am to 4:30pm
Phone: 905-525-9140 ext. 22065 Fax: 905-522-9033
The Faculty of Health Sciences is committed to providing a website that is accessible to the widest possible audience. If there is an accessibility issue with this website, please contact us at firstname.lastname@example.org.