Peer reviewed manuscripts

(2020-Oct) FK506-binding protein 13 expression is upregulated in interstitial lung disease and correlated with clinical severity: a potentially protective role.

• American Journal of Respiratory Cell and Molecular Biology (In Press)
• DOI: TBD
• Tat, V; Ayaub, E; Ayoub, A; Vierhout, M; Naiel, S; Padwal, M; Abed, S; Mekhael, O; Tandon, K; Revill, S; Yousof, T; Bellaye, PS; Kolb, P; Dvorkin-Gheva, A; Naqvi, A; Cutz, J; Hambly, N; Kato, J; Vaughan, M; Moss, J.; Kolb, M; Ask, K

(2020-Oct) Sub-optimal treatment response to anti-IL-5 monoclonal antibodies in severe eosinophilic asthmatics with airway autoimmune phenomena.

• European Respiratory Journal (In Press)
• DOI: 10.1183/13993003.00117-2020
• Mukherjee, M; Forero, D; Tran, S; Boulay, M; Bertrand, M; Bhalla, A; Cherukat, J; Al-Hayyan, H; Ayoub, A; Revill, S; Javkar, T; Radford, K; Kjarsgaard, M; Huang, C; Dvorkin-Gheva, A; Ask, K; Olivenstein, R; Dendukuri, N; Lemiere, C; Boulet, LP; Martin, J; Nair, P

(2020-Oct) Expression of endocannabinoid system components in human airway epithelial cells - Impact of sex and chronic respiratory disease status

• European Respiratory Journal Open Research (In Press)
• DOI: 10.1183/23120541.00128-2020
• Fantauzzi, M; Aguiar, J; Tremblay, B; Mansfield, M; Yanagihara, T; Chandiramohan, A; Revill, S; Ryu,M; Carlsten, C; Ask, K; Stämpfli, M; Doxey, A; Hirota, J

(2020-Sept) Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue.

• European Respiratory Journal (Published)
• DOI:10.1183/13993003.01123-2020
• Aguiar, J; Tremblay, B; Mansfield, M; Woody, O; Lobb, B; Banerjee, Al Chandiramohan, A; Tiessen, N; Cao, Q; Dvorkin-Gheva, A; Revill, S; Miller, M; Caristen, C; Organ, L; Joseph, C; John, A; Hanson, P; Austin, R; McManus, B; Jenkins, G; Mossman, K; Ask, K; Doxey, A; Hirota, J

(2020-Aug) Current models of pulmonary fibrosis for future drug discovery efforts.

• Expert Opinion on Drug Discovery (Published)
• DOI: 10.1080/17460441.2020.1755252
• Yanagihara, T; Chong, SG; Vierhout, M; Hirota, JA; Ask, K; Kolb, M

(2020-June) The importance of interventional timing in the bleomycin model of pulmonary fibrosis.

• European Respiratory Journal (Published)
• DOI: 10.1183/13993003.01105-2019
• Kolb, P; Upagupta, C; Vierhout, M; Ayaub, E; Bellaye, PS; Gauldie, J; Shimbori, C; Inman, M; Ask, K; Kolb, M
  

(2020-May) Protein misfolding and endoplasmic reticulum stress in chronic lung disease: will cell-specific targeting be the key to the cure? 

• Chest (Published)
• DOI: 10.1016/j.ches.2019.11.009
• Naiel, S; Tat, V; Padwal, M; Vierhout, M; Mekhael, O; Yousof, T; Ayoub, A; Abed, S; Dvorkin-Gheva, A; Ask, K

Abstracts

(2020-May) Characterizing the transcriptomic signature in circulating monocytes and alternatively activated macrophages in idiopathic pulmonary fibrosis 

• American Thoracic Society
• A62. Lung Fibrosis: Insights from the bench 
• Vierhout, M; Mekhael, O; Ayoub, A; Dvorkin-Gheva, A; Hayat, A; Chu, E; Revill, S; Padwal, M ;Cutz, J-C; Naqvi, A; Hirota, JA; Kolb, M; Hambly, N; Ask, K

(2020-May) Characterizing the role of ABCF1 in dsDNA antiviral responses in human airway epithelial cells

• American Thoracic Society
• D34. Infections and the immune response
• Cao, QT; Abbas, N; Aguiar, J; Tremblay, BJ-M; Doxey, A; Revill, S; Ayoub, A; Ask, K, Hirota JA

(2020-May) Intrinsic BMP inhibitor Gremlin regulates lung alveolar stem cell proliferation and differentiation

• American Thoracic Society
• D27. Cellular responses informing lung repair
• Zhou, Q; Yanagihara, T; Revill, S; Chong, SG; Dvorkin-Gheva, A; Ask, K; Kolb, M; Gauldie, J

(2020-May) Anti-inflammatory/anti-fibrotic compound PBI-4425 alleviates bleomycin-and TGF-ß1-Induced pulmonary fibrosis

• American Thoracic Society
• A68. Parenchyma/Intersitial lung disease
• Gagnon, L; Leduc, M; Tremblay, M; Shimbori, C; Sarra-Bournet, F; Felton, A; Yanagihara, T; Ask, K; Kolb, M; Leblond, FA; Grouix, B

(2020-May) The expression and genetic mutation of BMPR2 in the fibrotic lung diseases

• American Thoracic Society
• D109. Modulating the Fibrotic Response
• Yanagihara, T; Ayoub, A; Chong, M; Scallan, CJ; Zhou, Q; Chong, SG; Sato, S; Ask, K; Tikkanen, J; Keshavjee, S; Guillaume, P; Kolb, M

(2020-May) Integrative-Omics identify potential biomarkers and therapeutic targets for idiopathic pulmonary fibrosis

• American Thoracic Society
• A62. Lung Fibrosis: Insights from the bench 
• Yang, CX; Milne, S; Allen, R; Hernandez Cordero, AI; Li, X; Ayoub, A; Ask, K, Hirota, JA, Bossé, Y; Timens, W; Hao, K; Sin, DD; Jenkins, G; Wain, LV; Obeidat, M