Protein misfolding events has over the past 20 years been associated with the pathogenesis of multiple diseases, ranging from diseases of genetic origins (Cystic Fibrosis/1-alpha antitrypsin deficiency) to metabolic disorders (Diabetes) and Cancer.
We are interested to learn more about the molecular events that occur when proteins are not folded correctly in the endoplasmic reticulum (ER) and to elucidate the downstream activation of the Unfolded Protein Response (UPR) to clarify its possible role in disease initiation and progression.
(2020-Oct) FK506-binding protein 13 expression is upregulated in interstitial lung disease and correlated with clinical severity: a potentially protective role.
(2020-Aug) Current models of pulmonary fibrosis for future drug discovery efforts.
(2020-June) The importance of interventional timing in the bleomycin model of pulmonary fibrosis.
(2020-May) Characterizing the role of ABCF1 in dsDNA antiviral responses in human airway epithelial cells
(2020-May) Intrinsic BMP inhibitor Gremlin regulates lung alveolar stem cell proliferation and differentiation
(2020-May) The expression and genetic mutation of BMPR2 in the fibrotic lung diseases