Welcome to the Ask Lab

Role of protein misfolding in inflammation and chronic lung disease

Protein misfolding events has over the past 20 years been associated with the pathogenesis of multiple diseases, ranging from diseases of genetic origins (Cystic Fibrosis/1-alpha antitrypsin deficiency) to metabolic disorders (Diabetes) and cancer.

We are interested to learn more about the molecular events that occur when proteins are not folded correctly in the endoplasmic reticulum (ER) and to elucidate the downstream activation of the Unfolded Protein Response (UPR) to clarify its possible role in the initiation and progression of chronic lung disorders.

We believe that increased understanding of the molecular pathways involved in the response to cellular ER stress and protein misfolding events will enable us to identify novel molecular targets involved in both disease initiation and progression.

Recent Papers

(2020-Oct) FK506-binding protein 13 expression is upregulated in interstitial lung disease and correlated with clinical severity: a potentially protective role.

• American Journal of Respiratory Cell and Molecular Biology (In Press)
• DOI: TBD
• Tat, V; Ayaub, E; Ayoub, A; Vierhout, M; Naiel, S; Padwal, M; Abed, S; Mekhael, O; Tandon, K; Revill, S; Yousof, T; Bellaye, PS; Kolb, P; Dvorkin-Gheva, A; Naqvi, A; Cutz, J; Hambly, N; Kato, J; Vaughan, M; Moss, J.; Kolb, M; Ask, K

(2020-Oct) Sub-optimal treatment response to anti-IL-5 monoclonal antibodies in severe eosinophilic asthmatics with airway autoimmune phenomena.

• European Respiratory Journal (In Press)
• DOI: 10.1183/13993003.00117-2020
• Mukherjee, M; Forero, D; Tran, S; Boulay, M; Bertrand, M; Bhalla, A; Cherukat, J; Al-Hayyan, H; Ayoub, A; Revill, S; Javkar, T; Radford, K; Kjarsgaard, M; Huang, C; Dvorkin-Gheva, A; Ask, K; Olivenstein, R; Dendukuri, N; Lemiere, C; Boulet, LP; Martin, J; Nair, P

(2020-Oct) Expression of endocannabinoid system components in human airway epithelial cells - Impact of sex and chronic respiratory disease status

• European Respiratory Journal Open Research (In Press)
• DOI: 10.1183/23120541.00128-2020
• Fantauzzi, M; Aguiar, J; Tremblay, B; Mansfield, M; Yanagihara, T; Chandiramohan, A; Revill, S; Ryu,M; Carlsten, C; Ask, K; Stämpfli, M; Doxey, A; Hirota, J