Characterize Endoplasmic Reticulum (ER) stress, Unfolded Protein Response (UPR) and up-regulation of molecular chaperones in patients with Chronic Lung Disease
Investigate the role of ER stress and UPR in:
Cigarette Smoke-Induced Lung Disease
Investigate the link between ER stress and chronic inflammation
Role of protein misfolding in inflammation and chronic lung disease
Protein misfolding events has over the past 20 years been associated with the pathogenesis of multiple diseases, ranging from diseases of genetic origins (Cystic Fibrosis/1-alpha antitrypsin deficiency) to metabolic disorders (Diabetes) and cancer.
We are interested to learn more about the molecular events that occur when proteins are not folded correctly in the endoplasmic reticulum (ER) and to elucidate the downstream activation of the Unfolded Protein Response (UPR) to clarify its possible role in the initiation and progression of chronic lung disorders.
We believe that increased understanding of the molecular pathways involved in the response to cellular ER stress and protein misfolding events will enable us to identify novel molecular targets involved in both disease initiation and progression.
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