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Research at the Ask Lab
The Ask Lab researches the role of protein misfolding in inflammation and chronic lung disease.
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Research themes at the Ask Lab
Research themes include characterizing ER stress, UPR and upregulation of molecular chaperones in patients with chronic lung disease.
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Collaborations at the Ask Lab
The Ask Lab collaborates with experts from multi-disciplinary fields to further our research.
Welcome to the Ask Lab
Research themes:
- Characterize Endoplasmic Reticulum (ER) stress, Unfolded Protein Response (UPR) and up-regulation of molecular chaperones in patients with Chronic Lung Disease
- Investigate the role of ER stress and UPR in:
- Cigarette Smoke-Induced Lung Disease
- Pulmonary Fibrosis
- Investigate the link between ER stress and chronic inflammation
Role of protein misfolding in inflammation and chronic lung disease
Protein misfolding events has over the past 20 years been associated with the pathogenesis of multiple diseases, ranging from diseases of genetic origins (Cystic Fibrosis/1-alpha antitrypsin deficiency) to metabolic disorders (Diabetes) and cancer.
We are interested to learn more about the molecular events that occur when proteins are not folded correctly in the endoplasmic reticulum (ER) and to elucidate the downstream activation of the Unfolded Protein Response (UPR) to clarify its possible role in the initiation and progression of chronic lung disorders.
We believe that increased understanding of the molecular pathways involved in the response to cellular ER stress and protein misfolding events will enable us to identify novel molecular targets involved in both disease initiation and progression.
Recent Papers
(2020-Oct) FK506-binding protein 13 expression is upregulated in interstitial lung disease and correlated with clinical severity: a potentially protective role.
- American Journal of Respiratory Cell and Molecular Biology (In Press)
- DOI: TBD
- Tat, V; Ayaub, E; Ayoub, A; Vierhout, M; Naiel, S; Padwal, M; Abed, S; Mekhael, O; Tandon, K; Revill, S; Yousof, T; Bellaye, PS; Kolb, P; Dvorkin-Gheva, A; Naqvi, A; Cutz, J; Hambly, N; Kato, J; Vaughan, M; Moss, J.; Kolb, M; Ask, K
- European Respiratory Journal (In Press)
- DOI: 10.1183/13993003.00117-2020
- Mukherjee, M; Forero, D; Tran, S; Boulay, M; Bertrand, M; Bhalla, A; Cherukat, J; Al-Hayyan, H; Ayoub, A; Revill, S; Javkar, T; Radford, K; Kjarsgaard, M; Huang, C; Dvorkin-Gheva, A; Ask, K; Olivenstein, R; Dendukuri, N; Lemiere, C; Boulet, LP; Martin, J; Nair, P
- European Respiratory Journal Open Research (In Press)
- DOI: 10.1183/23120541.00128-2020
- Fantauzzi, M; Aguiar, J; Tremblay, B; Mansfield, M; Yanagihara, T; Chandiramohan, A; Revill, S; Ryu,M; Carlsten, C; Ask, K; Stämpfli, M; Doxey, A; Hirota, J
